USE OF INTRANASAL OXYTOCIN IN OBSTETRICS .1. A LABORATORY EVALUATION
USE OF INTRANASAL OXYTOCIN IN OBSTETRICS .1. A LABORATORY EVALUATION
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DOI：
10.1016/0002-9378(60)90636-0
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发表时间：
1960-01-01
影响因子：
9.8
通讯作者：
GABEL, RA
中科院分区：
文献类型：
--
作者：
HENDRICKS, CH;GABEL, RA
1.1.通过使用子宫内导管记录子宫活动，在一系列23名怀孕受试者中研究了鼻内施用合成催产素的效果，其中16名处于或超过足月，其余的分别在38、36、34、30、28、22和12周开始开始。该药物以滴剂或小塑料挤压瓶中的细喷雾的形式施用。3.3.给药后，子宫活动的任何增加通常出现在5至7分钟内。4.4.高峰活动通常在10至20分钟内达到，之后通常开始缓慢下降到自发活动的水平。单次瞬时鼻内应用该药物代表非常适度的剂量，其效果大致相当于每分钟2 mU催产素持续静脉输注5分钟所带来的效果。催产素刺激的收缩在所有特征上都与自发发生的收缩难以区分。鼻内催产素诱导的反应量主要取决于子宫先前对催产素的敏感程度。
1.1. With use of intrauterine catheters to record uterine activity, the effect of intranasal administration of synthetic oxytocin was studied in a series of 23 pregnant subjects, 16 of whom were at or beyond term, the remainder begin at 38, 36, 34, 30, 28, 22, and 12 weeks, respectively.2.2. The drug was applied either in drops or in the form of a fine spray from a small plastic squeeze bottle.3.3. Following administration of the drug, any increase in uterine activity usually appears within 5 to 7 minutes.4.4. The peak activity is usually achieved within 10 to 20 minutes, after which there usually begins a slow decline toward the level of spontaneous activity.5.5. A single instantaneous intranasal application of the drug represents a very modest dose, the effect being roughly comparable to that brought about by the continous intravenous infusion of 2 mU of oxytocin per minute for 5 minutes.6.6. The contractions stimulated by oxytocin are indistinguishable in all characteristics from spontaneously occurring contractions.7.7. The amount of response induced by intranasal oxytocin is principally dependent upon the degree of sensitivity to oxytocin which the uterus has previously achieved.