Sodium Intake and Vascular Smooth Muscle Responsiveness to Norepinephrine and Angiotensin in the Rabbit
Sodium Intake and Vascular Smooth Muscle Responsiveness to Norepinephrine and Angiotensin in the Rabbit
复制标题
兔的钠摄入量和血管平滑肌对去甲肾上腺素和血管紧张素的反应
DOI：
10.1161/01.res.31.5.758
复制
发表时间：
1972
影响因子：
20.1
通讯作者：
N. Hollenberg
中科院分区：
文献类型：
--
作者：
G. Strewler;Kathern J. Hinrichs;Linda R. Guiod;N. Hollenberg
在两种家兔血管平滑肌制备物中评估了饮食钠限制对去甲肾上腺素和血管紧张素反应的影响。限钠降低了体内肢体血管和体外主动脉对血管紧张素的反应。在两种制剂中，钠限制均增强了对去甲肾上腺素的反应。对血管紧张素反应性的影响似乎与快速耐受、细胞外电解质组成的变化或平滑肌功能的非特异性抑制无关。很可能，钠摄入量的变化诱导了平滑肌细胞膜的变化，从而改变了它们对血管紧张素和去甲肾上腺素受体的亲和力。
The effect of dietary sodium restriction on the responses to norepinephrine and angiotensin was assessed in two vascular smooth muscle preparations in the rabbit. Sodium restriction reduced the response to angiotensin of both the limb vessels in vivo and the aorta in vitro. The response to norepinephrine was potentiated by sodium restriction in both preparations. The effects on angiotensin responsiveness did not appear to be related to tachyphylaxis, changes in extracellular electrolyte composition, or nonspecific depression of smooth muscle function. Probably, the change in sodium intake induced a change in the smooth muscle cell membranes which modified the affinity of their receptors for angiotensin and norepinephrine.