[The influence of consecutive application of B-190 preparation and interleukin-1beta on survival rate and bone marrow hematopoiesis of irradiated mice].
[The influence of consecutive application of B-190 preparation and interleukin-1beta on survival rate and bone marrow hematopoiesis of irradiated mice].
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B-190制剂与白细胞介素1β连续应用对照射小鼠存活率及骨髓造血的影响
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
T. N. Vlasenko
中科院分区：
文献类型：
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作者：
A. N. Grebeniuk;V. Zatsepin;N. Aksenova;V. Nazarov;T. N. Vlasenko
本研究的目的是探讨放射防护剂B-190的连续应用对急性放射损伤白细胞介素-1 β（IL-1 β）的应急治疗效果。通过研究丢失动物的30天存活率和平均预期寿命，骨髓造血研究，估计给定的制剂导入回路的治疗和预防作用。已经确定，与单独引入相比，连续施用剂量为50 mg/kg的放射防护剂B-190直至照射15次，并且在照射后连续施用剂量为50 mg/kg的白介素-1 β直至照射15次，在更大程度上增加了受照射小鼠的存活率并防止了CFU-S9数量的减少。
The purpose of research was the experimental estimation of efficiency of consecutive application of a radioprotector B-190 and means of emergency therapy of radiating injury interleukin-1beta at acute irradiation. An estimation of treatment-and-prophylactic action of the given circuit of introduction of preparations carried out by studying 30 day-survival and average life expectancy of the lost animals, research of bone marrow hemopoiesis. It is established, that consecutive application of a radioprotector B-190 in a doze of 50 mg/kg for 15 mines up to an irradiation and interleukin-1beta in a doze of 50 mkg/kg through 15 mines after irradiating increases survival and prevents decrease in quantity of CFU-S9 at the irradiated mice in the greater degree, than their isolated introduction.