Nonenzymatic Self-Assembly Access to Diverse ortho-Quinone Methide-Based Pseudonatural Products.
Nonenzymatic Self-Assembly Access to Diverse ortho-Quinone Methide-Based Pseudonatural Products.
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DOI：
10.1021/acs.orglett.2c02268
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发表时间：
2022-07
期刊：
影响因子：
5.2
通讯作者：
Guangwei Wu;Xuan Qian;Yeqiang Huang;Yujia Liu;Luning Zhou;Wei Wang;Jing Li;T. Zhu;Q. Gu;Dehai Li
中科院分区：
文献类型：
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作者：
Guangwei Wu;Xuan Qian;Yeqiang Huang;Yujia Liu;Luning Zhou;Wei Wang;Jing Li;T. Zhu;Q. Gu;Dehai Li
介绍了一种非酶自组装程序，以探索海洋来源真菌中各种基于clavatol的伪天然产物（PNPs）。化学反应性的克拉瓦托醇邻醌与天然受体的分子间偶联产生了14个克拉瓦托基PNPs，共5类，化合物1、2、5-10和12为新化合物。特别是，1和2具有前所未有的oxa角四环支架，具有高度氧化修饰，并表现出细胞毒性。该程序已被证明在构建生物活性pnp方面具有很大的优势。
A nonenzymatic self-assembly program was introduced to explore diverse clavatol-based pseudonatural products (PNPs) in a marine-derived fungus. Intermolecular couplings of the chemoreactive ortho-quinone methide of clavatol with native acceptors led to 14 clavatol-based PNPs with five categories, and compounds 1, 2, 5-10, and 12 are new. In particular, 1 and 2 possessed an unprecedented oxa-angular tetracyclic scaffold with highly oxidized modification and exhibited cytotoxicity. Such a program is proven to be of great advantage in constructing bioactive PNPs.