HERPES-SIMPLEX VIRUS, CYTOMEGALOVIRUS AND EPSTEIN-BARR VIRUS-ANTIBODY TITERS IN SERA FROM SCHIZOPHRENIC-PATIENTS
HERPES-SIMPLEX VIRUS, CYTOMEGALOVIRUS AND EPSTEIN-BARR VIRUS-ANTIBODY TITERS IN SERA FROM SCHIZOPHRENIC-PATIENTS
复制标题
DOI：
10.1017/s0033291700011764
复制
发表时间：
1986-11-01
影响因子：
6.9
通讯作者：
GERSHON, ES
中科院分区：
文献类型：
--
作者：
DELISI, LE;SMITH, SB;GERSHON, ES
对38例无血缘关系的慢性精神分裂症患者、11个至少有2名精神分裂症成员的核心家庭和2个对照组进行单纯疱疹病毒（hsv - 1,2）、巨细胞病毒（CMV）和eb病毒衣壳抗原（EBV-VCA）血清抗体滴度测定。各组单纯性疱疹病毒和巨细胞病毒抗体滴度分布相似。患者抗ebv - vca滴度高于非住院对照组；然而，与患者接触的医院工作人员对EBV-VCA的抗体滴度也明显较高。同时对27例无亲缘关系患者和24名精神病院工作人员进行EBV- ea抗体检测。精神分裂症患者的EBV-EA抗体滴度明显高于医院工作人员对照组。这些数据不支持疱疹病毒与精神分裂症病因学有关的假设。虽然抗EBV早期抗原滴度升高可能提示持续的活动性EBV感染，但它不太可能与疾病的病因有关，因为EBV血清阳性在精神分裂症的兄弟姐妹中存在不一致。
Serum antibody titres to herpes-simplex (HSV-1, 2), cytomegalovirus (CMV), and Epstein–Barr virus capsid antigen (EBV-VCA) were determined in 38 unrelated chronic schizophrenic patients, 11 nuclear families with at least 2 schizophrenic members, and 2 control groups. The distributions of antibody titres to herpes simplex and cytomegalovirus were similar among all groups. Patients had higher anti-EBV-VCA titres than non-hospitalized controls; however, hospital staff members in contact with the patients also had significantly higher antibody titres to EBV-VCA. Antibodies to EBV early antigen (EBV-EA) were also determined for 27 unrelated patients and 24 mental hospital employees. The schizophrenic patients had significantly higher antibody titres to EBV-EA than the hospital worker control group. These data do not support the hypothesis that herpes viruses are associated with the aetiology of schizophrenia. Although elevated anti-EBV early antigen titres may suggest persistent active EBV infection, it is unlikely to be related to the aetiology of the disorder, since discordance for EBV seropositivity was present among sibling pairs concordant for schizophrenia.