Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response.
Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response.
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DOI：
10.1016/j.virol.2010.11.023
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发表时间：
2011-03-15
期刊：
影响因子：
3.7
通讯作者：
Campbell KP
中科院分区：
文献类型：
--
作者：
Oldstone MB;Campbell KP
病毒感染后的致病机制是病毒与宿主相互作用的结果。结果取决于病毒的毒力或宿主的易感性/抵抗力之间的平衡，偏向其中之一。本文主要介绍东半球新城疫病毒家族的两个重要成员：拉沙热病毒(LFV)和淋巴细胞性脉络膜脑膜炎病毒(LCMV)。拉沙热病毒是一种能引起严重急性出血性疾病的人类病原体，但在啮齿动物模型中更为人所知。对这一模型的研究揭示并阐明了我们目前在免疫生物学和病毒发病机制方面的许多概念。这里介绍了最新的进展，形成了框架，以更好地了解病毒如何诱导和维持持续感染，以及与急性LFV感染相关的发病机制。了解这些病毒发病机制的一个主要组成部分是研究病毒与其受体α-营养不良聚糖(α-DG)的相互作用。
Pathogenesis following a virus infection results from interactions between the virus and its host. The outcome is determined by tipping the balance between virulence of the virus or susceptibility/resistance of the host to favor one or the other. This review focuses on two important members of the Old World arenavirus family: Lassa fever virus (LFV), a robust human pathogen that causes a severe acute hemorrhagic disease; and lymphocytic choriomeningitis virus (LCMV), also a human pathogen but better known in the context of its rodent model. Research with this model has uncovered and illuminated many of our current concepts in immunobiology and viral pathogenesis. Presented here are recent advances that form the framework for a better understanding of how viruses induce and maintain persistent infection as well as for the pathogenesis associated with acute LFV infection. A major component for understanding the pathogenesis of these arenaviruses revolves around study of the interaction of virus with its receptor, alpha-dystroglycan (α-DG).
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