Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4-dihydroisoquinolin-3-ones.
Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4-dihydroisoquinolin-3-ones.
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DOI：
10.1021/cc100021t
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发表时间：
2010-04
影响因子：
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通讯作者：
Tingxuan Ma;Wenteng Chen;Guolin Zhang;Yongping Yu
中科院分区：
文献类型：
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作者：
Tingxuan Ma;Wenteng Chen;Guolin Zhang;Yongping Yu
发展了一种液相平行合成4-取代-1，4-二氢异喹啉-3-酮的有效方法。采用分子内Heck反应构建异喹啉酮，提供完整的区域和立体选择性。大多数合成的化合物对肿瘤细胞系表现出有效的抗增殖活性。
An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of the synthesized compounds showed potent antiproliferative activities against tumor cell lines.