Copper Single-Atom Jellyfish-like Nanomotors for Enhanced Tumor Penetration and Nanocatalytic Therapy.
Copper Single-Atom Jellyfish-like Nanomotors for Enhanced Tumor Penetration and Nanocatalytic Therapy.
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DOI：
10.1021/acsnano.3c00076
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发表时间：
2023-03
期刊：
影响因子：
17.1
通讯作者：
Yi Xing;Jidong Xiu;Mengyun Zhou;Tailin Xu;Meiqin Zhang;Hui Li;Xiaoyu Li;Xin Du;Tianyi Ma;Xueji Zhang
中科院分区：
文献类型：
--
作者：
Yi Xing;Jidong Xiu;Mengyun Zhou;Tailin Xu;Meiqin Zhang;Hui Li;Xiaoyu Li;Xin Du;Tianyi Ma;Xueji Zhang
单原子催化剂因其优异的催化活性而在肿瘤治疗中受到广泛关注。然而，大多数单原子催化剂缺乏自推进特性，限制了它们主动接近癌细胞或穿透肿瘤内部。在此，我们设计了氮掺杂的类介孔碳纳米马达与单原子铜（Cu-JMCNs）协调。它是单原子纳米催化药物和纳米发动机自推进的结合，用于癌症治疗。Cu单原子能催化H2 O2生成毒性的羟基自由基（·OH）用于化学动力学治疗（CDT）。近红外光激发Cu-JMCNs实现自热泳运动，这是由于碳的非对称结构和光热性质，显著提高了细胞摄取和三维肿瘤的穿透能力。体内实验表明，单原子铜的CDT和近红外光推进相结合，可以达到85%以上的肿瘤抑制率。这项工作揭示了先进的纳米电机与单原子催化剂的生物医学应用的发展。
Single-atom catalysts with extraordinary catalytic activity have been receiving great attention in tumor therapy. However, most single-atom catalysts lack self-propulsion properties, restricting them from actively approaching cancer cells or penetrating the interior of tumors. Herein, we design N-doped jellyfish-like mesoporous carbon nanomotors coordinated with single-atom copper (Cu-JMCNs). It is a combination of single-atom nanocatalytic medicine and nanomotor self-propulsion for cancer therapy. The Cu single atom can catalyze H2O2 into toxic hydroxyl radical (•OH) for chemodynamic therapy (CDT). Near-infrared light triggers Cu-JMCNs to achieve self-thermophoretic motion because of the jellyfish-like asymmetric structure and photothermal property of carbon, which significantly improves the cellular uptake and the penetration of three-dimensional tumors. In vivo experiments indicate that the combination of single-atom Cu for CDT and near-infrared light propulsion can achieve over 85% tumor inhibition rate. This work sheds light on the development of advanced nanomotors with single-atom catalysts for biomedical applications.