Consolidation of Complex Events via Reinstatement in Posterior Cingulate Cortex
Consolidation of Complex Events via Reinstatement in Posterior Cingulate Cortex
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DOI：
10.1523/jneurosci.1774-15.2015
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发表时间：
2015-10-28
影响因子：
5.3
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
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作者：
Bird, Chris M.;Keidel, James L.;Burgess, Neil
众所周知，积极的复述可以提高记忆巩固的效果。还已知的是，参考先验知识来解释复杂事件。然而，相对较少的关注已经给予这些影响的神经基础。在健康的成年人中，我们通过向人们展示几个简短的视频片段，然后要求他们在MRI扫描仪中大声回忆这些片段（实验1）或安静地回忆这些片段（实验2），研究了努力，主动排练对事件记忆的影响。在这两个实验中，一周后的测试中，积极排练的片段比未经排练的片段记忆得更详细。在实验1中，高度相似的事件描述产生了检索试验，这表明一定程度的语义化的记忆已经发生。在实验2中，BOLD信号在内侧颞区和后中线区域的空间模式相关时，编码和排练相同的视频。此外，后扣带回中这种相关性的强度预测了随后回忆起的信息量。这可能反映了视频内容的表现力的加强。我们认为，这些表征结合联合收割机新的情节信息和存储的语义知识（或“模式”）。因此，我们认为，后中线结构有助于巩固恢复和加强情节细节和更一般的示意性信息之间的关联。这导致了对逼真的、复杂的事件的连贯记忆表征的产生，这些记忆表征抵抗遗忘，但本质上有些不灵活和语义相似。
It is well-established that active rehearsal increases the efficacy of memory consolidation. It is also known that complex events are interpreted with reference to prior knowledge. However, comparatively little attention has been given to the neural underpinnings of these effects. In healthy adults humans, we investigated the impact of effortful, active rehearsal on memory for events by showing people several short video clips and then asking them to recall these clips, either aloud (Experiment 1) or silently while in an MRI scanner (Experiment 2). In both experiments, actively rehearsed clips were remembered in far greater detail than unrehearsed clips when tested a week later. In Experiment 1, highly similar descriptions of events were produced across retrieval trials, suggesting a degree of semanticization of the memories had taken place. In Experiment 2, spatial patterns of BOLD signal in medial temporal and posterior midline regions were correlated when encoding and rehearsing the same video. Moreover, the strength of this correlation in the posterior cingulate predicted the amount of information subsequently recalled. This is likely to reflect a strengthening of the representation of the video's content. We argue that these representations combine both new episodic information and stored semantic knowledge (or "schemas"). We therefore suggest that posterior midline structures aid consolidation by reinstating and strengthening the associations between episodic details and more generic schematic information. This leads to the creation of coherent memory representations of lifelike, complex events that are resistant to forgetting, but somewhat inflexible and semantic-like in nature.