TOWARDS COMPUTING BRAIN DEFORMATIONS FOR DIAGNOSIS, PROGNOSIS AND NEUROSURGICAL SIMULATION
TOWARDS COMPUTING BRAIN DEFORMATIONS FOR DIAGNOSIS, PROGNOSIS AND NEUROSURGICAL SIMULATION
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DOI：
10.1142/s0219519405001254
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发表时间：
2005-03-01
影响因子：
0.8
通讯作者：
Nowinski, Wieslaw L.
中科院分区：
文献类型：
--
作者：
Miller, Karol;Taylor, Zeike;Nowinski, Wieslaw L.
我们的研究目标是创建一个计算大脑变形的系统。我们着眼于临床和培训应用，例如“脑转移”计算、脑疾病发展的预后和诊断，以及用于规划和教育的手术模拟器。在本文中，我们专门解决有关创建大脑的几何和机械精确表示的问题。该方法包括以下步骤：（1）开发3D解剖脑图谱，（2）构建图谱的有限元网格，（3）创建数学模型，以及（4）开发有效的计算模型。我们讨论了两种类型的方法来模拟大脑的变形行为：单相脑组织模型，适用于分析相对较短的事件，如手术动作;和双相脑组织模型，非常适合计算导致疾病的发展的预后。作为所提出的概念的说明，我们提供了3D网格化的例子，使用单相数学模型计算作用在手术工具上的反作用力，以及使用双相建模方法计算脑积水的发展和肿瘤生长的影响。
The objective of our research is to create a system computing brain deformations. We have in view both clinical and training applications, such as "brain shift" calculation, prognosis and diagnosis of development of brain diseases as well as surgical simulators for planning and education. In this paper, we specifically address issues related to creating geometrically and mechanically precise representations of the brain. The method comprises of the following steps: (1) development of a 3D anatomical brain atlas, (2) construction of a finite element mesh of the atlas, (3) creation of a mathematical model, and (4) development of an efficient computational model. We discuss two types of approaches to model deformation behavior of the brain: single-phase brain tissue model, suitable for analysis of relatively short events such as surgical actions; and bi-phasic brain tissue model, well suited for calculations leading to prognosis of the development of diseases. As an illustration of the presented concepts we provide examples of 3D meshing, calculation of reaction force acting on a surgical tool using a single-phase mathematical model, and calculations of the development of hydrocephalus and the effects of tumor growth using the bi-phasic modeling approach.