Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.
Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.
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DOI：
10.1146/annurev-bioeng-071114-040640
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发表时间：
2015
影响因子：
9.7
通讯作者：
Rando TA
中科院分区：
文献类型：
--
作者：
Bursac N;Juhas M;Rando TA
尽管骨骼肌是我们身体中再生能力最强的器官之一，但各种遗传缺陷、外在信号的改变或严重的组织损伤会损害肌肉功能和自我修复能力。肌肉疾病的多样性和复杂性引起了细胞生物学家以及近期生物工程师的极大兴趣，促使人们集中精力更好地理解肌肉病理学并开发更有效的治疗方法。这篇综述描述了肌肉发育、修复和疾病的生物学基础，并讨论了近期生物工程在设计和控制类肌环境方面所做的努力，这些努力既用于研究肌肉生物学和功能，也有助于开发针对肌肉疾病的新的药物、细胞和基因疗法。工程辅助的生物学发现与受生物学启发的工程解决方案之间的协同作用将是把实验室成果转化为临床实践的前进道路。
Although skeletal muscle is one of the most regenerative organs in our body, various genetic defects, alterations in extrinsic signaling, or substantial tissue damage can impair muscle function and the capacity for self-repair. The diversity and complexity of muscle disorders have attracted much interest from both cell biologists and, more recently, bioengineers, leading to concentrated efforts to better understand muscle pathology and develop more efficient therapies. This review describes the biological underpinnings of muscle development, repair, and disease, and discusses recent bioengineering efforts to design and control myomimetic environments, both to study muscle biology and function and to aid in the development of new drug, cell, and gene therapies for muscle disorders. The synergy between engineering-aided biological discovery and biology-inspired engineering solutions will be the path forward for translating laboratory results into clinical practice.