Linoleic acid, other fatty acids, and the risk of stroke
Linoleic acid, other fatty acids, and the risk of stroke
复制标题
DOI：
10.1161/01.str.0000023890.25066.50
复制
发表时间：
2002-08-01
期刊：
影响因子：
8.3
通讯作者：
Shimamoto, T
中科院分区：
文献类型：
--
作者：
Iso, H;Sato, S;Shimamoto, T
背景和目的——血清脂肪酸作为中风和中风亚型危险因素的作用在很大程度上尚不清楚。 方法——一项针对日本 40 至 85 岁年龄段的前瞻性巢式病例对照研究，通过使用 1984 年至 1989 年 1 个社区和 1989 年至 1992 年其他 2 个社区收集的 7450 名心血管风险调查参与者的冷冻血清样本进行。到 1998 年底，我们确定了 197 例中风，其亚型通过影像学研究得到证实。通过匹配性别、年龄、社区、血清储存年份和禁食状态，每个病例选择三个对照。结果-与对照相比，总中风（n=197）、出血性中风（n=75）和缺血性中风（n=122）的n3多不饱和脂肪酸比例相似，亚油酸和花生四烯酸比例较低，饱和和单饱和脂肪酸比例较高 酸，通过气相色谱法测定。调整高血压、糖尿病、血清总胆固醇和其他心血管危险因素后，与亚油酸 (5%) 增加 1-SD 相关的多变量比值比为：总卒中为 0.72 [95% 置信区间 (CI)，0.59 至 0.89]，缺血性卒中为 0.66（95% CI，0.49 至 0.88），缺血性卒中为 0.63（95%）。 腔隙性脑梗塞的 CI，0.46 至 0.88），出血性中风的 CI，0.81（95% CI，0.59 至 1.12）。饱和脂肪酸（4％）的比值比分别为1.13（95％CI，1.05至1.65）、1.35（95％CI，1.01至1.79）、1.44（95％CI，1.03至2.01）和1.21（95％CI，0.82至1.80）。对其他脂肪酸的进一步调整减弱了这些关系，但亚油酸与缺血性中风风险之间的关系仍然具有统计学意义。 结论：较高的亚油酸摄入量可能通过降低血压、减少血小板聚集和增强红细胞变形能力的潜在机制来预防缺血性中风。
Background and Purpose-The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown.Methods-A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status.Results-Compared with controls, total (n=197), hemorrhagic (n=75), and ischemic (n=122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5%) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95% confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95% CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95% CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95% CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4%) were 1.13 (95% CI, 1.05 to 1.65), 1.35 (95% CI, 1.01 to 1.79), 1.44 (95% CI, 1.03 to 2.01), and 1.21 (95% CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant.Conclusions-A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells.