DEVELOPMENT OF A CROHNS INDEX FOR SURVEY-RESEARCH
DEVELOPMENT OF A CROHNS INDEX FOR SURVEY-RESEARCH
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DOI：
10.1016/0895-4356(88)90046-7
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发表时间：
1988-01-01
影响因子：
7.2
通讯作者：
KUPPER, LL
中科院分区：
文献类型：
--
作者：
SANDLER, RS;JORDAN, MC;KUPPER, LL
目前的克罗恩S疾病活跃度指数不适合调查研究，因为它们依赖于实验室或体检的信息。我们使用了柳氮磺胺吡啶的多中心对照试验的数据，根据只能通过访谈获得的信息，开发了一个关于克隆病活动性的指数。研究人群包括在8个医疗中心1082次就诊的89名有症状的活跃患者。多元回归分析确定了预测医生评级的三个变量：大便频率、腹痛和幸福感。新的指数与克隆氏S疾病活动性指数有很好的相关性(r=0.87p<；0.001)。该指数可用于流行病学研究，以准确地将患者归入疾病严重程度的四分位数，对应于CDAI的类似四分位数。
Current Crohn''s disease activity indices are not suitable for survey research because they rely on information from the laboratory or physical examination. We used data from a multicenter controlled trial of adjuvant sulfasalazine to develop an index of Crohn''s disease activity based on information which could be obtained exclusively by interview. The study population consisted of 89 actively symptomatic patients seen on 1082 occasions in eight medical centers. Multiple regression analyses identified three variables which predicted the ratings of physicians: stool frequency, abdominal pain and sense of well-being. The new index correlated very well (r = 0.87, p < 0.001) with the Crohn''s Disease Activity Index from which it was derived. The index may be used in epidemiologic studies to accurately place patients into quartiles of disease severity which correspond to similar quartiles of the CDAI.