Electrochemical reduction and voltammetric determination of metronidazole at a nanomaterial thin film coated glassy carbon electrode
Electrochemical reduction and voltammetric determination of metronidazole at a nanomaterial thin film coated glassy carbon electrode
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DOI：
10.1016/j.talanta.2003.12.005
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发表时间：
2004-06-17
期刊：
影响因子：
6.1
通讯作者：
Hu, SS
中科院分区：
文献类型：
--
作者：
Lu, SF;Wu, KB;Hu, SS
报道了一种基于纳米碳膜电极(GCE)测定甲硝唑的简便灵敏的电化学方法。在疏水表面活性剂的存在下，将多壁碳纳米管分散到水中，得到稳定、均匀的多壁碳纳米管悬浮液，并通过挥发溶剂制备了多壁碳纳米管薄膜包覆的GCE。在pH 9.0的Britton-Robinson缓冲溶液中，甲硝唑在MWNT膜修饰的GCE上产生一个清晰的还原峰，其电位为-0.71V。与裸露的GCE相比。MWNT膜修饰的GCE显著提高了甲硝唑的还原峰电流。对甲硝唑的测定条件进行了优化。在累积2分钟时，检出限为6×10~(-9)mol/1。该方法已成功地用于药物中甲硝唑的测定。并与分光光度法进行了比较。(C)2003爱思唯尔B.V.保留所有权利。
Simple and sensitive electrochemical method for the determination of metronidazole, based on a nanostructured film coated glassy carbon electrode (GCE), is described. Multi-walled carbon nanotubes (MWNT) was dispersed into water in the presence of a hydrophobic surfactant to give very stable and homogeneous MWNT suspension, and a MWNT-film coated GCE was achieved via evaporating solvent. Metronidazole yields a well-defined reduction peak whose potential is -0.71 V at the MWNT-film coated GCE in pH 9.0 Britton-Robinson buffer. Compared with bare GCE. the MWNT-film modified GCE significantly enhances the reduction peak current of metronidazole. All the experimental parameters were optimized for the determination of metronidazole. The detection limit is 6 x 10(-9) mol/1 at 2 min accumulation. This method has been successfully used to determine metronidazole in the drugs. Furthermore, results obtained by the proposed method have been compared with spectrophotometric method. (C) 2003 Elsevier B.V. All rights reserved.