Alcohol drinking as an unfavorable prognostic factor for male patients with nasopharyngeal carcinoma.
Alcohol drinking as an unfavorable prognostic factor for male patients with nasopharyngeal carcinoma.
复制标题
DOI：
10.1038/srep19290
复制
发表时间：
2016-01-18
影响因子：
4.6
通讯作者：
Xia YF
中科院分区：
文献类型：
--
作者：
Chen YP;Zhao BC;Chen C;Lei XX;Shen LJ;Chen G;Yan F;Wang GN;Chen H;Jiang YQ;Xia YF
饮酒与鼻咽癌预后的关系尚不清楚。为探讨饮酒对鼻咽癌预后的影响，对1923例男性鼻咽癌患者进行回顾性研究。根据饮酒情况，将患者分为当前饮酒者、既往饮酒者和非饮酒者。此外，根据饮酒的强度和持续时间，他们被分为重度饮酒者和轻度/无饮酒者。采用Kaplan-Meier分析和考克斯比例风险模型比较生存结局。我们发现，与不饮酒者相比，目前饮酒者的总生存率（OS）（5年OS：70.2% vs. 76.4%，P < 0.001）和局部无复发生存率（LRFS）（5年LRFS：69.3% vs. 77.5%，P < 0.001）显著降低。饮酒≥14杯/周和饮酒≥20年均为OS的独立不利预后因素（风险比[HR] = 1.38，95%CI [CI] 1.05-1.81，P = 0.022; HR = 1.38，95%CI 1.09-1.75，P = 0.007）。分层分析进一步显示，酒精的负面影响主要表现在老年患者和吸烟者中。结论：饮酒是预测男性鼻咽癌患者预后的一个有用指标，饮酒者，尤其是重度饮酒者预后较差。
The relationship between alcohol drinking and the prognosis of nasopharyngeal carcinoma (NPC) is unknown. To investigate the prognostic value of alcohol drinking on NPC, this retrospective study was conducted on 1923 male NPC patients. Patients were classified as current, former and non-drinkers according to their drinking status. Furthermore, they were categorized as heavy drinkers and mild/none drinkers based on the intensity and duration of alcohol drinking. Survival outcomes were compared using Kaplan–Meier analysis and Cox proportional hazards model. We found that current drinkers had significantly lower overall survival (OS) rate (5-year OS: 70.2% vs. 76.4%, P < 0.001) and locoregional recurrence-free survival (LRFS) rate (5-year LRFS: 69.3% vs. 77.5%, P < 0.001) compared with non-drinkers. Drinking ≥14 drinks/week, and drinking ≥20 years were both independent unfavorable prognostic factors for OS (hazard ratio [HR] = 1.38, 95% confidence interval [CI] 1.05–1.81, P = 0.022; HR = 1.38, 95% CI 1.09–1.75, P = 0.007). Stratified analyses further revealed that the negative impacts of alcohol were manifested mainly among older patients and among smokers. In conclusion, alcohol drinking is a useful predictor of prognosis in male NPC patients; drinkers, especially heavy drinkers have poorer prognosis.