Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review.
Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review.
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JAK2/STAT3 信号通路在肿瘤发生、化疗耐药和实体瘤治疗中的作用：系统评价。
DOI：
10.2147/jir.s353489
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发表时间：
2022
影响因子：
4.5
通讯作者：
Chekol Abebe E
中科院分区：
文献类型：
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作者：
Mengie Ayele T;Tilahun Muche Z;Behaile Teklemariam A;Bogale Kassie A;Chekol Abebe E
Janus激酶2/信号转导及转录激活因子3（JAK2/STAT3）通路是一种常见的信号通路，当细胞因子和生长因子与特定细胞表面受体的胞外结构域结合时，用于将信号从细胞外转导至细胞内（细胞核）。该信号通路受到严格调控，具有多种生物学功能，如细胞增殖、分化和凋亡。此外，受调控的JAK2/STAT3信号在胚胎发育、造血以及免疫系统的控制中起着至关重要的作用。相反，异常激活的JAK2/STAT3在多种肿瘤中频繁被检测到，并参与许多对标准化疗通常耐药的癌症疾病的肿瘤发生、血管生成和转移。然而，有趣的是，JAK3/STAT3通路最近作为开发新型抗肿瘤药物的新靶点崭露头角，并成为治疗许多实体恶性肿瘤的有前景的治疗靶点。在此，本综述旨在深入了解JAK2/STAT3通路，希望了解其在实体肿瘤的发病机制、进展、化疗耐药性和癌症治疗中的潜在作用。
Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a common signaling pathway used to transduce signals from the extracellular to the intracellular (nucleus) upon the binding of cytokines and growth factors to the extracellular domain of specific cell surface receptors. This signaling pathway is tightly regulated and has a multitude of biological functions such as cell proliferation, differentiation, and apoptosis. Besides, the regulated JAK2/STAT3 signaling plays a crucial role in embryonic development, hemopoiesis, and controlling the immune system. Conversely, aberrantly activated JAK2/STAT3 is frequently detected in varieties of tumors and involved in oncogenesis, angiogenesis, and metastasis of many cancer diseases that are usually refractory to the standard chemotherapy. However, the JAK3/STAT3 pathway recently emerged interestingly as a new site for the development of novel anti-tumor agents and becomes a promising therapeutic target in the treatment of many solid malignancies. Herein, this review aimed to provide insight into the JAK2/STAT3 pathway, in the hope to gain an understanding of its potential role in the pathogenesis, progression, chemotherapy resistance, and cancer therapy of solid tumors.
影响因子：
5.2
作者：
Benabbou N;Mirshahi P;Cadillon M;Soria J;Therwath A;Mirshahi M
通讯作者：
Mirshahi M