High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers
High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers
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DOI：
10.1073/pnas.1204460109
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发表时间：
2012-11-06
影响因子：
11.1
通讯作者：
Bravin, Alberto
中科院分区：
文献类型：
--
作者：
Zhao, Yunzhe;Brun, Emmanuel;Bravin, Alberto
乳房x线摄影是筛查和诊断人类乳腺癌的主要成像工具，但在乳房x线摄影上无法检测到约10-20%的可触及肿瘤，只有约40%的活检病变是恶性的。在这里，我们报告了一种用于人类乳腺癌三维诊断的高分辨率，低剂量相衬x射线断层扫描方法。通过相衬x射线成像与一种称为等倾斜断层成像的图像重建方法相结合，我们对人类乳房进行了三维成像，并确定了一个恶性肿瘤，其像素大小为92 μ m，辐射剂量小于双视图乳房x线摄影。根据5位独立放射科医师的盲法评估，我们的方法相对于传统的相对比x射线断层扫描，可以在保持高图像分辨率和图像对比度的同时，将辐射剂量和采集时间减少74%左右。这些结果表明，原则上，人类乳腺癌的高分辨率3D诊断成像可以在临床相容剂量下进行。
Mammography is the primary imaging tool for screening and diagnosis of human breast cancers, but similar to 10-20% of palpable tumors are not detectable on mammograms and only about 40% of biopsied lesions are malignant. Here we report a high-resolution, low-dose phase contrast X-ray tomographic method for 3D diagnosis of human breast cancers. By combining phase contrast X-ray imaging with an image reconstruction method known as equally sloped tomography, we imaged a human breast in three dimensions and identified a malignant cancer with a pixel size of 92 mu m and a radiation dose less than that of dual-view mammography. According to a blind evaluation by five independent radiologists, our method can reduce the radiation dose and acquisition time by similar to 74% relative to conventional phase contrast X-ray tomography, while maintaining high image resolution and image contrast. These results demonstrate that high-resolution 3D diagnostic imaging of human breast cancers can, in principle, be performed at clinical compatible doses.