Fluorescence tomography in turbid media based on acousto-optic modulation imaging
Fluorescence tomography in turbid media based on acousto-optic modulation imaging
复制标题
DOI：
10.1063/1.2364600
复制
发表时间：
2006-10-30
影响因子：
4
通讯作者：
Takeda, Motohiro
中科院分区：
文献类型：
--
作者：
Kobayashi, Masaki;Mizumoto, Takashi;Takeda, Motohiro
作者提出了一种光散射介质中荧光的断层成像技术。基于超声波和光之间的相互作用的荧光超声波调制被应用于通过扫描其中光被选择性调制的聚焦声场来对荧光材料进行成像。确定了通过调制光的振幅（通过折射率和散射系数的变化）来影响光的轴上声场特性。该成像技术使用在致密散射介质中包含局部荧光区域的组织模型进行了演示，表明该技术可用于生物组织中荧光探针的可视化。 (c) 2006 年美国物理研究所。
The authors present a tomographic imaging technique of fluorescence in light-scattering media. Ultrasonic modulation of fluorescence based on the interaction between ultrasound and light is applied for imaging of a fluorescent material by scanning a focused sound field in which the light is modulated selectively. The on-axis sound-field characteristics that affect the light by modulating its amplitude (through variation of the refractive index and the scattering coefficient) were determined. That imaging technique is demonstrated using tissue phantoms that contain localized fluorescent regions in a dense scattering medium, suggesting the applicability of this technique for visualization of fluorescent probes in biological tissues. (c) 2006 American Institute of Physics.