Long-term effects of inhaled nicotine
Long-term effects of inhaled nicotine
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DOI：
10.1016/0024-3205(96)00100-2
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发表时间：
1996-03-15
期刊：
影响因子：
6.1
通讯作者：
Brenna, E
中科院分区：
文献类型：
--
作者：
Waldum, HL;Nilsen, OG;Brenna, E
据报道，吸烟与心血管疾病和癌症，特别是肺部疾病的风险增加有关。尽管对吸烟对健康的影响进行了广泛的研究，但烟草烟雾中对健康产生这些负面影响的物质还不完全清楚。尼古丁是一种给人以吸烟的主观快感的物质，同时也会使人上瘾。我们首次报道了长期（2年）吸入尼古丁对大鼠的影响。这些老鼠在一个含有尼古丁的房间里呼吸，尼古丁浓度是重度吸烟者血浆浓度的两倍。在两年的时间里，每周5天，每天20小时服用尼古丁。与对照组相比，我们没有发现这些大鼠的死亡率、动脉粥样硬化或肿瘤频率有任何增加。特别是显微镜和肉眼均未见肺肿瘤，肺神经内分泌细胞未见增加。然而，在整个研究过程中，与对照组相比，接触尼古丁的大鼠的体重有所减轻。总之，我们的研究表明，吸入纯形式的尼古丁没有任何有害影响。
Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction.For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.