Repeated lung injury due to alpha-naphthylthiourea causes right ventricular hypertrophy in rats.
Repeated lung injury due to alpha-naphthylthiourea causes right ventricular hypertrophy in rats.
复制标题
α-萘基硫脲引起的反复肺损伤会导致大鼠右心室肥厚。
DOI：
10.1152/jappl.1984.56.2.388
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Rounds,S
中科院分区：
文献类型：
--
作者：
Hill,NS;O'Brien,RF;Rounds,S
α-萘基硫脲 (ANTU) 引起的急性肺损伤与通透性水肿增加、短暂性肺动脉高压和血管反应性增加有关。我们试图确定重复施用 ANTU 是否会导致右心室肥厚。大鼠每周注射 ANTU 或等体积的吐温 80，持续 4 周。以 5-10 mg/kg 体重的剂量重复注射 ANTU 的大鼠右心室与左心室加间隔重量的比率增加。 ANTU治疗大鼠的右心室肥厚与右心室收缩期高血压相关。重复注射 ANTU 还会在每次给药后引起短暂性肺水肿，4 小时后肺湿干重量比增加即可证明，24 小时后恢复正常。与注射 Tween 80 的大鼠相比，注射 ANTU 的大鼠的肺对缺氧和血管紧张素 II 的升压反应更大。单独用 ANTU 或 Tween 重复治疗的大鼠的离体肺压力-流量曲线、动脉血气和血细胞比容相似。 ANTU 和对照肺的肺组织学也相似，动脉中层厚度和动脉数量/100 个肺泡的比率的测量结果也相似，表明尚未发生实质性血管重塑。因此，大鼠每周注射四次 ANTU 会导致右心室肥厚，这可能是由于肺动脉高压所致。我们推测肺动脉高压至少部分是由于持续的血管收缩造成的，而持续的血管收缩在某种程度上是由反复的急性肺损伤造成的。
Acute lung injury due to alpha-naphthylthiourea (ANTU) is associated with increased permeability edema, transient pulmonary hypertension, and increased vascular reactivity. We sought to determine whether repeated administration of ANTU caused right ventricular hypertrophy. Rats were injected weekly for 4 wk with ANTU or an equivalent volume of the vehicle Tween 80. Rats injected repeatedly with ANTU in doses of 5–10 mg/kg body wt had increased ratios of right ventricular to left ventricular plus septal weights. The right ventricular hypertrophy in ANTU-treated rats was associated with right ventricular systolic hypertension. Repeated injections of ANTU also caused transient pulmonary edema after each dose, as evidenced by increased wet-to-dry lung weight ratios after 4 h, which returned to normal by 24 h. Lungs isolated from ANTU-injected rats had greater pressor responses to hypoxia and to angiotensin II than lungs from Tween 80-injected rats. Pressure-flow curves of isolated lungs, arterial blood gases, and hematocrits were similar in rats treated repetitively with ANTU or Tween alone. Lung histology was also similar in ANTU and control lungs, as were measurements of arterial medial thickness and ratios of numbers of arteries/100 alveoli, indicating that substantial vascular remodeling had not occurred. Thus, four weekly ANTU injections in rats caused right ventricular hypertrophy, probably due to pulmonary hypertension. We speculate that the pulmonary hypertension was due, at least in part, to sustained vasoconstriction, which somehow resulted from repeated acute lung injury.