Thymus Colonization: Who, How, How Many?
Thymus Colonization: Who, How, How Many?
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DOI：
10.1007/s00005-017-0503-5
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发表时间：
2018-04
影响因子：
3.2
通讯作者：
A. Krueger
中科院分区：
文献类型：
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作者：
A. Krueger
T 细胞的从头生成取决于骨髓来源的祖细胞在胸腺的持续定植。胸腺播种祖细胞 (TSP) 构成包含多能和谱系限制细胞类型的异质群体。胸腺微环境的进入受到严格控制，最近的定量研究表明，成年小鼠胸腺仅包含约 160 个适应 TSP 的生态位。在这些利基市场中，平均只有约 6% 的利基市场在稳定状态下可供播种。在这里，我回顾了对成年小鼠胸腺定植的理解状态，特别关注该领域过去和当前的争议。在预处理方案过程中改善胸腺定植和/或维持完整的 TSP 生态位可能对于造血干细胞移植后有效的 T 细胞再生至关重要。
De novo generation of T cells depends on continual colonization of the thymus by bone marrow-derived progenitors. Thymus seeding progenitors (TSPs) constitute a heterogeneous population comprising multipotent and lineage-restricted cell types. Entry into the thymic microenvironment is tightly controlled and recent quantitative studies have revealed that the adult murine thymus only contains approximately 160 niches to accommodate TSPs. Of these niches only about 6% are open for seeding on average at steady-state. Here, I review the state of understanding of colonization of the adult murine thymus with a particular focus on past and current controversies in the field. Improving thymus colonization and/or maintaining intact TSP niches during the course of pre-conditioning regimens are likely to be critical for efficient T-cell regeneration after hematopoietic stem cell transplantation.