Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models
Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models
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DOI：
10.1016/j.biortech.2009.07.021
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发表时间：
2009-12-01
影响因子：
11.4
通讯作者：
Shetty, Kalidas
中科院分区：
文献类型：
--
作者：
Pinto, Marcia Da Silva;Kwon, Young-In;Shetty, Kalidas
四种不同银杏叶。在5个月期间（从2007年6月到10月）收集在相同条件下生长的树（1和2 -雌性; 3和4 -雄性）。分析了水和12%乙醇提取物的总酚含量、抗氧化活性、酚谱以及对与糖尿病和高血压管理相关的α-淀粉酶、α-葡萄糖苷酶和血管紧张素I转化酶（ACE）的潜在体外抑制作用。结果表明，在叶提取物中评价的所有功能效益中，树木之间存在显着差异，并且还发现与相同功能参数相关的重要季节变化。一般来说，水提取物的总酚含量高于乙醇提取物。此外，总酚和抗氧化活性之间没有相关性。在ACE抑制方面，只有乙醇提取物具有抑制活性。(C)2009爱思唯尔有限公司保留所有权利。
Leaves from four different Ginkgo biloba L. trees (1 and 2 - females; 3 and 4 - males), grown at the same conditions, were collected during a period of 5 months (from June to October, 2007). Water and 12% ethanol extracts were analyzed for total phenolics content, antioxidant activity, phenolic profile, and the potential in vitro inhibitory effects on alpha-amylase, alpha-glucosidase, and Angiotensin I-Converting Enzyme (ACE) enzymes related to the management of diabetes and hypertension. The results indicated a significant difference among the trees in all functional benefits evaluated in the leaf extracts and also found important seasonal variation related to the same functional parameters. In general, the aqueous extracts had higher total phenolic content than the ethanolic extracts. Also, no correlation was found between total phenolics and antioxidant activity. In relation to the ACE inhibition, only ethanolic extracts had inhibitory activity. (C) 2009 Elsevier Ltd. All rights reserved.