Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases.
Wernicke's encephalopathy: a more common disease than realised. A neuropathological study of 51 cases.
复制标题
韦尼克脑病：一种比人们意识到的更常见的疾病。
DOI：
--
复制
发表时间：
1979
影响因子：
11
通讯作者：
C. Harper
中科院分区：
文献类型：
--
作者：
C. Harper
在四年的时间里，尸检时诊断出51例韦尼克脑病，占皇家珀斯医院和珀斯市验尸官进行的所有尸检的1.7%。只有七个人在生前被诊断出患有癌症。许多病人突然意外死亡，显然是由于脑干出血性病变，这是典型的急性韦尼克脑病，因为没有发现其他死亡原因，癫痫发病率很高，四名病人体温过低。除非对脑进行组织学检查，否则尸检时可能漏诊韦尼克脑病。脑萎缩和脑室扩张是常见的表现。这是一种比通常认识到的更常见的疾病，可以很容易地治疗，更重要的是，通过适当的营养来预防。
During a four year peirod, 51 cases of Wernicke's encephalopathy were diagnosed at necropsy, an incidence of 1.7% of all necropsies performed at the Royal Perth Hospital and by the Perth City coroner. Only seven had been diagnosed during life. Many of the patients died suddenly and unexpectedly, apparently as a result of haemorrhagic brainstem lesions, typical of acute Wernicke's encephalopathy, since no other cause of death was found. There was a high incidence of epilepsy and four patients were hypothermic. The diagnosis of Wernicke's encephalopathy may be missed at necropsy unless the brain is examined histologically. Cerebral atrophy and ventricular dilatation were common findings. This is a more common disease than is generally recognised, one which can be readily treated and, more importantly, prevented by adequate nutrition.