Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.
Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.
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DOI：
10.1364/boe.6.001812
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发表时间：
2014-04
影响因子：
3.4
通讯作者：
M. Eberle;Carissa L. Reynolds;J. Szu;Yan Wang;Mike S. Hsu;D. Binder;B. H. Park
中科院分区：
文献类型：
--
作者：
M. Eberle;Carissa L. Reynolds;J. Szu;Yan Wang;Mike S. Hsu;D. Binder;B. H. Park
光学相干断层扫描（OCT）是一种高分辨率、微创的成像技术，可以产生深度分辨的横截面图像。在这项研究中，光学相干断层扫描被用来检测在体内的小鼠皮质组织的光学特性的变化，在全球（戊四氮）和局灶性（4-氨基吡啶）癫痫发作的诱导。通过对衰减系数的深度分辨体积使用置信区间统计方法，我们展示了表现出衰减系数显著正变化和负变化的区域的定位，以及区分全局和局灶性癫痫发作传播。
Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.