Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone
Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone
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DOI：
10.1002/ajpa.24686
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发表时间：
2023-01-09
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影响因子：
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通讯作者：
Tung，Jenny
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文献类型：
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作者：
Fogel，Arielle S.;Oduor，Peter O.;Tung，Jenny
对于任何哺乳动物来说，怀孕失败都是一项重要的健康成本，尤其是那些生活缓慢的动物，如灵长类动物。在这里，我们量化了野生杂交狒狒胎儿丢失的风险，包括遗传、生态和人口统计学的差异来源。我们特别感兴趣的是检验杂交会增加胎儿损失率的假设。这种效应将有助于解释狒狒如何在种间基因流动的情况下保持遗传和表型的完整性。材料和方法我们分析了46年来在自然黄狒狒-阿努比斯狒狒杂交区内观察到的1020例妊娠的结果。根据女性生殖状态和活产新生儿的外观记录对胎儿损失和活产进行评分。我们使用二项混合效应模型，将胎儿丢失的概率建模为女性遗传祖先的函数（估计其基因组的比例来自anubis [vs. yellow]祖先），年龄，先前胎儿丢失的数量，优势等级，群体规模，气候和栖息地质量。结果女性遗传血统不能预测胎儿丢失。相反，对于非常年轻和非常年老的女性来说，胎儿丢失的风险更高。胎儿损失最可靠的预测是生态因素，包括在家庭范围转移之前的栖息地质量差和怀孕期间的极端高温。我们的研究结果表明，黄狒狒和阿努比斯狒狒之间的基因流动不受杂交雌性胎儿丢失风险增加的阻碍。相反，生态条件和女性年龄是女性生殖成功的关键决定因素。
ObjectivesPregnancy failure represents a major fitness cost for any mammal, particularly those with slow life histories such as primates. Here, we quantified the risk of fetal loss in wild hybrid baboons, including genetic, ecological, and demographic sources of variance. We were particularly interested in testing the hypothesis that hybridization increases fetal loss rates. Such an effect would help explain how baboons may maintain genetic and phenotypic integrity despite interspecific gene flow.Materials and MethodsWe analyzed outcomes for 1020 pregnancies observed over 46 years in a natural yellow baboon‐anubis baboon hybrid zone. Fetal losses and live births were scored based on records of female reproductive state and the appearance of live neonates. We modeled the probability of fetal loss as a function of a female's genetic ancestry (the proportion of her genome estimated to be descended from anubis [vs. yellow] ancestors), age, number of previous fetal losses, dominance rank, group size, climate, and habitat quality using binomial mixed effects models.ResultsFemale genetic ancestry did not predict fetal loss. Instead, the risk of fetal loss is elevated for very young and very old females. Fetal loss is most robustly predicted by ecological factors, including poor habitat quality prior to a home range shift and extreme heat during pregnancy.DiscussionOur results suggest that gene flow between yellow and anubis baboons is not impeded by an increased risk of fetal loss for hybrid females. Instead, ecological conditions and female age are key determinants of this component of female reproductive success.