Apparent mesonephric duct (rete anlage) origin for cysts and proliferative epithelial lesions in the mouse ovary
Apparent mesonephric duct (rete anlage) origin for cysts and proliferative epithelial lesions in the mouse ovary
复制标题
DOI：
10.1080/01926230290105785
复制
发表时间：
2002-09-01
影响因子：
1.5
通讯作者：
Long, GG
中科院分区：
文献类型：
--
作者：
Long, GG
对不同月龄CD-1小鼠的卵巢及邻近卵巢旁(系膜)组织进行了检查，以观察卵巢及卵巢旁组织的囊性和增殖性上皮病变。取大约3个月和8个月大的6只小鼠的卵巢和邻近组织进行光学显微镜检查，并对整个组织的阶梯切片(间隔50亩)进行检查。取16~24月龄小鼠各40只，每只取3个台阶切片。3个月和8个月时，所有小鼠均可见中肾管残留。导管通常位于卵巢中膜脂肪组织中，靠近卵巢门或卵巢门内，常与卵巢中膜韧带的平滑肌松散相连。导管上皮由低立方到柱状，偶见个别细胞纤毛，偶见小乳头状上皮。与3个月相比，8个月时小鼠的卵巢导管扩张(1毫米)的频率更高，有些是连续的，卵巢内有囊状间隙。随着小鼠年龄的增长(16-24个月)，导管扩张和囊性改变，以及与之相关的卵巢组织远离卵巢门的压缩变得常见。扩张的导管上皮一般扁平，但可见立方至柱状上皮灶和/或偶见纤毛细胞。许多导管内有增生和/或肥大的上皮，偶见上皮乳头状突起。后者的一些病变与乳头状囊腺瘤的诊断一致。伴发的纤维肌肉间质增生仅限于少数明显的卵巢外导管。本研究的结果表明，残留的中肾导管结构在CD-1小鼠的卵巢及其附近很常见。随着小鼠年龄的增长，这些导管变得扩张，在某些情况下，上皮细胞变得肥大和/或肥大。这些中肾管残留物似乎是小鼠卵巢和卵巢旁细胞色素沉着综合征和卵巢上皮性肿瘤的常见来源。
Ovaries and adjacent parovarian (mesovarial) tissues of CD-1 mice of various ages were examined to characterize cystic and proliferative epithelial lesions of the ovary and parovarian tissues. Ovaries and adjacent tissues from 6 mice each at approximately 3 and 8 months of age were processed for light microscopy and step-sections (50-mu intervals) of the entire tissue were examined. Tissues were collected from 40 mice each at 16 through 24 months of age and 3 step sections per mouse were examined. Mesonephric duct remnants were found in all mice at 3 and 8 months. Ducts were usually in the mesovarial adipose tissue and near or within the ovarian hilus and were often loosely associated with smooth muscle of the mesovarial ligament. The epithelium of the ducts varied from low cuboidal to columnar, occasional individual cells were ciliated, and small papillary configurations of epithelium were occasionally present. Ducts were dilated (>1 mm) more often in mice at 8 months compared to 3 months, and some were continuous with cystic spaces within the ovaries. As mice aged (16-24 months), dilation and cystic change in ducts and associated compression of ovarian tissue away from the ovarian hilus became common. The epithelium of dilated ducts was generally flattened, but foci of cuboidal to columnar epithelium and/or occasional ciliated cells were present. Many ducts contained foci of hyperplastic and/or hypertrophic epithelium, and papillary projections of epithelium were occasionally found. Some of the latter lesions were consistent with a diagnosis of papillary cystadenoma. Hyperplasia of associated fibromuscular stroma was limited to a few apparently extraovarian ducts. The results of this study indicate that remnant mesonephric ductular structures are common in and adjacent to the ovaries of CD-1 mice. As mice age, these ducts become dilated and, in some, the epithelium becomes hyperplastic and/or hyperptrophic. These mesonephric duct remnants appear to be a common source of ovarian and parovarian cyts cysts and epithelial neoplasms of the ovary in mice.