Evolution of mitochondrial-type cytochrome c domains and of the protein machinery for their assembly
Evolution of mitochondrial-type cytochrome c domains and of the protein machinery for their assembly
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DOI：
10.1016/j.jinorgbio.2007.02.001
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Rosato, Antonio
中科院分区：
文献类型：
--
作者：
Bertini, Ivano;Cavallaro, Gabriele;Rosato, Antonio
含有线粒体型细胞色素 c 结构域的蛋白质（此处定义为具有线粒体细胞色素 c 折叠的蛋白质结构域）存在于生命各个领域的生物体中，并且构成了几种不同代谢途径中的必需成分。即使对于非常密切相关的生物体，特定生物体中存在的细胞色素 c 结构域的数量及其功能作用也可能存在很大差异。在这项工作中，我们详细分析了线粒体型细胞色素 c 结构域沿生命树的分布，并试图定义它们之间的进化关系。同时，我们还类似地分析了细胞色素 c 组装的不同机制的发生和分布。研究发现，线粒体型细胞色素 c 结构域及其组装装置的首次出现很可能发生在细菌世界中。细胞色素 c 结构域的进化非常广泛，涉及多个基因复制和基因转移事件。特别相关的是从细菌到真核生物和古细菌的基因转移事件。编码细胞色素c结构域的基因的转移通常与组装机器的转移同时发生。这种情况也发生在真核亚，但后者随后被新机器取代。在三种已知的细胞色素 c 组装酶系统中，系统 11（在蓝藻和革兰氏阳性细菌等中发现）可能是最古老的。古生菌继承自细菌系统 I，或者可能是系统 11 和系统 I 之间的进化中间体。(c) 2007 Elsevier Inc. 保留所有权利。
Proteins containing mitochondrial-type cytochrome c domains, defined here as protein domains having the mitochondrial cytochrome c fold, are found in organisms from all domains of life, and constitute essential components in several different metabolic pathways. The number of cytochrome c domains present in a given organism as well as their functional roles can vary widely even for quite closely related organisms. In this work, we have analysed in detail the distribution of mitochondrial-type cytochrome c domains along the tree of life and attempted to define the evolutionary relationships among them. In parallel, we have similarly analysed also the occurrence and distribution of the different machineries for cytochrome c assembly. It is found that the first appearance of mitochondrial-type cytochrome c domains has likely happened in the bacterial world, together with the first apparatus for their assembly. Evolution of cytochrome c domains has been extensive, involving several gene duplication and gene transfer events. Of particular relevance are gene transfer events from Bacteria to Eukarya and Archaea. The transfer of genes encoding cytochrome c domains has generally co-occurred with transfer of the assembly machinery. This has occurred also in Eukarya, where however the latter machinery has been subsequently replaced by a new one. It is possible that of the three known enzymatic systems for cytochrome c assembly, system 11 (found, among others, in cyanobacteria and Gram-positive bacteria) is the most ancient. Archaea have inherited from Bacteria system I or, possibly, an evolutionary intermediate between system 11 and system I. (c) 2007 Elsevier Inc. All rights reserved.