Embryonic development -: Maternal effect of Hsf1 on reproductive success
Embryonic development -: Maternal effect of Hsf1 on reproductive success
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DOI：
10.1038/35037669
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发表时间：
2000-10-12
期刊：
影响因子：
64.8
通讯作者：
Benjamin, IJ
中科院分区：
文献类型：
--
作者：
Christians, E;Davis, AA;Benjamin, IJ
一种称为热休克因子-1 (HSF1) 的蛋白质是响应环境变化的应激诱导基因的主要反式激活因子，但它也与小鼠的胚胎外发育和雌性生育能力有关。在这里，我们发现，尽管卵母细胞可以正常排卵和受精，但母亲缺乏这种蛋白质的小鼠胚胎无法在合子阶段之后正常发育。野生型精子不能使受精卵免于死亡，这表明缺乏该因子的雌性的生殖失败是由“母体效应”突变引起的，而来自母亲的HSF1通常控制着受精后的早期发育。
A protein known as heat-shock factor-1 (HSF1) is a major transactivator of stress-inducible genes in response to environmental changes, but it is also implicated in extra-embryonic development and female fertility in mice,. Here we show that mouse embryos whose mothers lack this protein are unable to develop properly beyond the zygotic stage, although oocytes were ovulated and fertilized normally. Wild-type spermatozoa do not save zygotes from lethality, indicating that the reproductive failure of females deficient in this factor is caused by a 'maternal effect' mutation, and that HSF1 from the mother normally controls early post-fertilization development.