Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells
Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells
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DOI：
10.4049/jimmunol.179.7.4535
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Belz, Gabrielle T.
中科院分区：
文献类型：
--
作者：
Waithman, Jason;Allan, Rhys S.;Belz, Gabrielle T.
皮肤引流淋巴结含有许多不同来源的树突状细胞亚群。其中一些是迁移性的，如皮肤来源的表皮朗格汉斯细胞和单独的真皮DC亚群，而另一些则是淋巴性的，如遍布淋巴组织的CD8(+) DC。在这项研究中，我们研究了在稳态和局部皮肤感染条件下，迁移性和淋巴驻留DC皮肤源性自银的DC亚群表现。我们表明，在这两种情况下，自体银的呈现仅限于皮肤来源的迁移dc。稳态呈现导致T细胞耐受缺失，尽管这些dc表达相对成熟的表型，如MHC II类和CD86表达水平等传统标记物。因此，自体银可以通过皮肤来源的dc携带到引流淋巴结，并在那里由这些相同的细胞呈现，以耐受循环T细胞池。
Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets of different origins. Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8(+) DCs found throughout the lymphoid tissues. In this study, we examine the DC subset presentation of skin-derived self-Ag by migratory and lymphoid-resident DCs, both in the steady state and under conditions of local skin infection. We show that presentation of self-Ag is confined to skin-derived migrating DCs in both settings. Steady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression. Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool.