Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma.
Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma.
复制标题
靶向空心金纳米球介导的光声成像和光热消融治疗对神经胶质瘤原位小鼠异种移植模型的影响。
DOI：
10.1158/0008-5472.can-10-4557
复制
发表时间：
2011-10-01
期刊：
影响因子：
11.2
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Lu W;Melancon MP;Xiong C;Huang Q;Elliott A;Song S;Zhang R;Flores LG 2nd;Gelovani JG;Wang LV;Ku G;Stafford RJ;Li C
纳米技术的进步使得创造多功能纳米结构成为可能，这些纳米结构可以同时用于成像和治疗癌症。例如，中空金纳米球（HAuNS）已被证明产生强烈的光声信号并诱导有效的光热消融（PTA）治疗。在这项研究中，我们使用光声断层扫描（PAT），一种混合成像方式，以评估HAuNS靶向整合素的静脉内递送，这些整合素在胶质瘤和血管生成血管的小鼠胶质瘤模型中过表达。然后用近红外激光治疗小鼠，使肿瘤温度升高20.7 °C。我们发现PTA治疗显著延长了荷瘤小鼠的生存期。总之，这些结果证明了使用单个纳米结构进行使用光声分子成像的图像引导的局部肿瘤PTA治疗的可行性。
Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography (PAT), a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7 °C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results demonstrate the feasibility of using a single nanostructure for image-guided local tumor PTA therapy using photoacoustic molecular imaging.