Clinical and epidemiological features of group A streptococcal bacteraemia in a region with hyperendemic superficial streptococcal infection
Clinical and epidemiological features of group A streptococcal bacteraemia in a region with hyperendemic superficial streptococcal infection
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DOI：
10.1017/s0950268898001952
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发表时间：
1999-02-01
影响因子：
4.2
通讯作者：
Currie, BJ
中科院分区：
文献类型：
--
作者：
Carapetis, JR;Walker, AM;Currie, BJ
关于侵袭性A组链球菌（GAS）感染的发病率和严重程度增加的报告主要来自富裕人群，这些人群接触GAS相对较少。我们对澳大利亚北领地的GAS菌血症进行了一项B年回顾性研究，将其他链球菌感染和后遗症发生率较高的土著人口（占研究人口的24%）与非土著人口进行了比较。在72次发作中，44次（61%）发生在土著患者中。所有12例儿童病例均为土著人。82%的发作涉及风险因素（成人为91%），与至少有一个风险因素的非土著患者相比，土著患者的比例没有显著差异。分离株的基因分型显示没有优势菌株，也没有证据表明存在克隆，而克隆是其他地方感染的常见原因。
Reports of increasing incidence and severity of invasive group A streptococcal (GAS) infections come mainly from affluent populations where exposure to GAS is relatively infrequent. We conducted a B-year retrospective review of GAS bacteraemia in the Northern Territory of Australia, comparing the Aboriginal population (24% of the study population), who have high rates of other streptococcal infections and sequelae, to the non-Aboriginal population. Of 72 episodes, 44 (61%) were in Aboriginal patients. All 12 cases in children were Aboriginal. Risk factors were implicated in 82 % of episodes (91 % in adults) and there was no significant difference in the proportion of Aboriginal compared to non-Aboriginal patients with at least one risk factor. Genetic typing of isolates revealed no dominant strains and no evidence of a clone which has been a common cause of these infections elsewhere.