The risk of bladder cancer in patients diagnosed with other primary neoplasms: Analysis of the SEER database
The risk of bladder cancer in patients diagnosed with other primary neoplasms: Analysis of the SEER database
复制标题
DOI：
10.1016/j.urolonc.2011.06.005
复制
发表时间：
2013-08-01
影响因子：
2.7
通讯作者：
Slaton, Joel
中科院分区：
文献类型：
--
作者：
Anderson, J. Kyle;Alanee, Shaheen;Slaton, Joel
目的：我们评估了患者的历史，以前的恶性肿瘤，以确定风险的一个随后的bladder cancer.Materials和Methods：美国国家癌症研究所的监测，流行病学，和最终结果9注册数据库从1973年至1999年（SEER）进行了审查，为患者的初始原发性癌症在口腔和咽，结肠和直肠，呼吸系统，乳腺癌，前列腺癌，睾丸，或阴茎。然后对这组患者进行检查，以确定随后单独的膀胱原发性恶性肿瘤。与普通人群中膀胱癌的发病率进行比较，以确定标准化发病率（SIR）。根据诊断时的年龄、分期、性别、种族和使用外照射治疗初始cancer.Results进行额外分析：共有7，289例（0.5%）患者在初始恶性肿瘤后发生膀胱癌。前列腺癌患者患膀胱癌的风险增加最大，SIR为8.24，所有初始癌症组的膀胱癌风险相对于普通人群升高。外照射和非白人性别与膀胱癌风险增加相关。年龄较大的初始癌症的诊断与随后的膀胱cancer.Conclusions的风险较低：这项研究表明，膀胱癌的风险增加后，一个单独的初始癌症。降低这些患者膀胱癌的阈值可能是必要的。(C)2013 Elsevier Inc. All rights reserved.
Objective: We evaluated patients with history of previous malignancy to determine risk of an ensuing bladder cancer.Materials and methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results 9 registry database from 1973 to 1999 (SEER) was reviewed for patients with initial primary cancers in oral cavity and pharynx, colon and rectum, respiratory system, breast, prostate, testis, or penis. This group of patients was then examined to identify subsequent separate primary malignancies in the bladder. Comparison was made to the incidence of bladder cancer in the general population to determine a standardized incidence ratio (SIR). Additional analysis was performed based on age at diagnosis, stage, gender, race, and use of external beam radiation for treatment of initial cancer.Results: A total of 7,289 (0.5%) of patients had a bladder cancer following their initial malignancy. Patients with prostate cancer had the largest increase in risk of bladder cancer with a SIR of 8.24, and all initial cancer groups had an elevated risk of bladder cancer relative to the general population. External beam radiation and non-White gender were associated with an increased risk of bladder cancer. Older age at diagnosis of the initial cancer correlated with a lower risk of subsequent bladder cancer.Conclusions: This study suggests an increased risk of bladder cancer following a separate initial cancer. Lower threshold for working up those patients for bladder cancer may be warranted. (C) 2013 Elsevier Inc. All rights reserved.