Dietary lactose improves endochondral growth and bone development and mineralization in rats fed a vitamin D-deficient diet.
Dietary lactose improves endochondral growth and bone development and mineralization in rats fed a vitamin D-deficient diet.
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DOI：
10.1093/jn/118.1.72
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Scott C. Miller;Michael A. Miller;T. Omura
中科院分区：
文献类型：
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作者：
Scott C. Miller;Michael A. Miller;T. Omura
乳糖促进肠道吸收钙独立于维生素D内分泌系统。本研究的目的是确定补充乳糖对饲喂维生素d缺乏饲料的断奶大鼠软骨内骨生长、骨发育和矿化的影响。将缺乏维生素d的幼鼠断奶，喂食缺乏维生素d的饮食，其中含有蔗糖作为主要碳水化合物来源，或喂食含有20%乳糖的类似饮食。4周后，乳糖喂养的大鼠体重、血清钙水平和软骨内骨伸长率均高于蔗糖喂养的大鼠。此外，乳糖喂养大鼠的骨重、骨钙含量、骨灰量占骨干重的百分比、干骺端骨组织百分比和骨类骨含量也与蔗糖喂养大鼠不同。在所有情况下，在饲喂乳糖补充饮食的动物中观察到的骨组织变化与饲喂维生素d补充饮食的年龄匹配的动物中观察到的正常值一致。补充乳糖对骨骼生长和发育的改善与维生素D内分泌系统无关，可能是肠道钙吸收改善的结果。
Lactose promotes the intestinal absorption of calcium independent of the vitamin D endocrine system. The purpose of this study was to determine the effect of lactose supplementation on endochondral bone growth, bone development and mineralization in weanling rats fed a vitamin D-deficient diet. Rat pups were weaned from vitamin D-deficient dams and fed a vitamin D-deficient diet containing sucrose as the primary carbohydrate source or a similar diet but containing 20% lactose. After 4 wk, body weights, serum calcium levels and endochondral bone elongation rates in the lactose-fed animals were higher than in rats fed the sucrose diet. In addition, bone weights, bone calcium content, percent bone ash of bone dry weight, percent metaphyseal osseous tissues and bone osteoid content in the lactose-fed rats were different from those in the rats fed the sucrose diet. In all cases the changes in osseous tissues that were observed in the animals fed the lactose-supplemented diet were toward normal values as observed in age-matched animals fed a vitamin D-replete diet. The improvements in bone growth and development due to lactose supplementation occurred independent of the vitamin D endocrine system and are likely the result of improved calcium absorption in the intestine.