Differential Distribution of Neurons in the Gyral White Matter of the Human Cerebral Cortex
Differential Distribution of Neurons in the Gyral White Matter of the Human Cerebral Cortex
复制标题
DOI：
10.1002/cne.22485
复制
发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
DeFelipe, J.
中科院分区：
文献类型：
--
作者：
Garcia-Marin, V.;Blazquez-Llorca, L.;DeFelipe, J.
皮层白色物质中的神经元（WM神经元）起源于从脑室区迁移的第一组有丝分裂后神经元。特别地，它们出现在包含端脑中产生的最早细胞的亚板中，在灰质皮质层中的神经元出现之前。这些皮质WM神经元在发育期间数量非常多，当它们被认为参与瞬时突触网络时，尽管这些细胞中的许多细胞后来死亡，并且相对较少的细胞在成人中作为WM神经元存活。我们使用光学和电子显微镜来分析WM神经元在成人大脑皮层的各个区域中的分布和密度。此外，我们检查了这些神经元的体周神经支配并估计了白色物质中突触的密度。最后，我们检查了支配WM神经元胞体的中间神经元的分布和神经化学性质。从获得的数据中，我们可以得出三个主要结论：第一，WM神经元的密度根据皮质区域而变化，第二，钙视黄蛋白免疫反应神经元代表GABA能WM神经元的主要亚群，第三，WM神经元的胞体被谷氨酸能和GABA能轴突终末包围，尽管只发现对称的轴体突触。相比之下，在神经元中观察到对称和不对称的轴-树突突触。我们讨论了这些发现在皮质回路方面的可能的功能意义J Comp Neurol 518 4740-4759，2010（C）2010 Wiley利斯公司
The neurons in the cortical white matter (WM neurons) originate from the first set of postmitotic neurons that migrates from the ventricular zone In particular, they arise in the subplate that contains the earliest cells generated in the telencephalon, prior to the appearance of neurons in gray matter cortical layers These cortical WM neurons are very numerous during development, when they are thought to participate in transient synaptic networks, although many of these cells later die, and relatively few cells survive as WM neurons in the adult We used light and electron microscopy to analyze the distribution and density of WM neurons in various areas of the adult human cerebral cortex Furthermore, we examined the perisomatic innervation of these neurons and estimated the density of synapses in the white matter Finally, we examined the distribution and neurochemical nature of interneurons that putatively innervate the somata of WM neurons From the data obtained, we can draw three main conclusions first, the density of WM neurons varies depending on the cortical areas, second, calretinin-immunoreactive neurons represent the major subpopulation of GABAergic WM neurons, and, third, the somata of WM neurons are surrounded by both glutamatergic and GABAergic axon terminals, although only symmetric axosomatic synapses were found By contrast, both symmetric and asymmetric axodendritic synapses were observed in the neuropil We discuss the possible functional implications of these findings in terms of cortical circuits J Comp Neurol 518 4740-4759, 2010 (C) 2010 Wiley Liss Inc