Elevated c-myc expression in progeria fibroblasts.
Elevated c-myc expression in progeria fibroblasts.
复制标题
早衰成纤维细胞中 c-myc 表达升高。
DOI：
10.1016/s0006-291x(88)80595-3
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
R. Hart
中科院分区：
文献类型：
--
作者：
K. Nakamura;A. Turturro;R. Hart
在被诊断为哈钦森-吉尔福德综合征（早衰症）的供体中培养的人成纤维细胞中测定原癌基因的表达。与正常父母对照和不相关、未受影响、年龄匹配的对照相比，早衰细胞中c-myc表达水平升高。在两个早衰培养中，观察到incc -myc表达增加150%，而第三个早衰培养，随后被确定为非经典早衰，显示incc -myc表达增加45%。Southern blot分析未发现c-mycgene的扩增或易位。在- erbbc -src原癌基因的表达上没有发现显著差异。
Protooncogene expression was determined in cultured human fibroblasts derived from donors diagnosed with Hutchinson-Gilford Syndrome (Progeria). An increased level ofc-mycexpression was noted in progeria cells compared to normal parental controls and unrelated, unaffected, age-matched controls. In two progeria cultures a 150% increase inc-mycexpression was observed, while a third progeria culture, subsequently identified as a non-classic progeria showed a 45% increase inc-mycexpression. Southern blot analysis did not indicate an amplification or translocation of thec-mycgene. No significant differences were found in the expression of thec-erbBorc-srcprotooncogenes.