Voltage and Spike Timing Interact in STDP - A Unified Model.
Voltage and Spike Timing Interact in STDP - A Unified Model.
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DOI：
10.3389/fnsyn.2010.00025
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发表时间：
2010
影响因子：
3.7
通讯作者：
Gerstner W
中科院分区：
文献类型：
--
作者：
Clopath C;Gerstner W
突触可塑性的现象学模型能够解释大量的发放时间依赖性可塑性（STDP）的实验数据。该模型的基本组成部分是突触前锋电位到达与突触后电压的相关性。局部膜电压被使用两次：第一项用于瞬时电压，第二项用于低通滤波电压迹线。尖峰时间效应是一个特例。我们假设电压依赖性可以解释STDP在树突中的差异效应，因为反向传播动作电位或树突棘波的幅度和时间过程影响模型中的可塑性结果。树突效应通过在突触部位的电压时间过程的可变选择来模拟，即，没有神经元空间结构的明确模型。
A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on spike-timing-dependent plasticity (STDP). The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a first term accounts for the instantaneous voltage and the second one for a low-pass filtered voltage trace. Spike-timing effects emerge as a special case. We hypothesize that the voltage dependence can explain differential effects of STDP in dendrites, since the amplitude and time course of backpropagating action potentials or dendritic spikes influences the plasticity results in the model. The dendritic effects are simulated by variable choices of voltage time course at the site of the synapse, i.e., without an explicit model of the spatial structure of the neuron.