Anisotropic mechanical properties of tissue components in human atherosclerotic plaques
Anisotropic mechanical properties of tissue components in human atherosclerotic plaques
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DOI：
10.1115/1.1800557
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发表时间：
2004-10-01
影响因子：
1.7
通讯作者：
Regitnig, P
中科院分区：
文献类型：
--
作者：
Holzapfel, GA;Sommer, G;Regitnig, P
了解人类动脉粥样硬化斑块的生物力学特性对于深入了解心血管系统的病理生理学和更好地预测介入治疗（如球囊血管成形术）的结果至关重要。现有的数据主要是基于单轴试验，而且大多数研究都是研究纤维斑块帽的力学响应。然而，例如球囊血管成形术期间的应力分布受到动脉粥样硬化病变所有组成部分的强烈影响。对来自9条人类高度狭窄髂动脉的107个样本进行了测试；相关供体的记忆报告。采用磁共振成像技术检测采集动脉的可用性。组织学分析有助于确定不同组织类型的特征。对制备的7种不同组织类型的条带进行轴向和周向循环准静态单轴拉伸试验；记录了极限拉伸应力和拉伸。单个样品的实验数据表明各向异性和高度非线性的组织特性以及相当大的标本间差异。然而，钙化表现为线性性质，与观察到的高应力区域外膜的刚度大致相同。钙化断裂处的应力和拉伸值分别为179+/-56 kf'a和1.02+/-0.005 kf'a。在所研究的所有内膜组织中，纤维帽周向的骨折应力最低（拉伸1.182+/-0.1时为254.8+/-79.8 kPa）。外膜的机械强度最高，未患病介质的机械强度最低。
Knowledge of the biomechanical properties of human atherosclerotic plaques is of essential importance for developing more insights in the pathophysiology of the cardiovascular system and for better predicting the outcome of interventional treatments such as balloon angioplasty. Available data are mainly based on uniaxial tests, and most of the studies investigate the mechanical response of fibrous plaque caps on However stress distributions during, for example, balloon angioplasty are strongly influenced by all components of atherosclerotic lesions. A total number of 107 samples from nine human high-grade stenotic iliac arteries were tested; associated anamnesis of donors reported. Magnetic resonance imaging was employed to test the usability of the harvested arteries. Histological analyses has served to characterize the different tissue types. Prepared strips of 7 different tissue types underwent cyclic quasistatic uniaxial tension tests in axial and circumferential directions; ultimate tensile stresses and stretches were documented. Experimental data of individual samples indicated anisotropic and highly nonlinear tissue properties as well as considerable interspecimen differences. The calcification showed, however, a linear property, with about the same stiffness as observed for the adventitia in high stress regions. The stress and stretch values at calcification fracture are smaller (179+/-56 kf'a and 1.02+/-0.005) than for each of the other tissue components. Of all intimal tissues investigated, the lowest fracture stress occurred in the circumferential direction of the fibrous cap (254.8+/-79.8 kPa at stretch 1.182+/-0.1). The adventitia demonstrated the highest and the nondiseased media the lowest mechanical strength oil average.