Future Sexual Medicine Physiological Treatment Targets
Future Sexual Medicine Physiological Treatment Targets
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DOI：
10.1111/j.1743-6109.2010.02025.x
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Xin, Zhong C.
中科院分区：
文献类型：
--
作者：
Burnett, Arthur L.;Goldstein, Irwin;Xin, Zhong C.
介绍：男性和女性的性功能包括中枢和外周神经系统、血管系统和内分泌系统的生理过程和调节。有必要为国家的最先进的信息，因为有一个不断发展的研究了解的基础分子生物学因素和机制，支配性生理功能。目的。对负责性生理功能的生物系统的主要细胞和分子靶点的当前知识的最新共识报告。艺术知识代表了来自4个国家的7位专家的意见，在2年的时间里，在一个共识的过程中发展。主要结果测量。专家意见是基于循证医学文献的分级，广泛的内部委员会讨论，公众介绍，结果：需要在这一领域进行科学研究，以增加知识，促进对所有形式的生物性性功能障碍的未来治疗路线的发展。本文介绍了目前的知识，主要的细胞和分子的生物系统负责性生理功能的目标。未来的治疗目标包括生长因子治疗，基因治疗，干细胞和细胞为基础的治疗，和再生medicine.Conclusions.科学发现是至关重要的，在性医学开发新的和越来越有效的治疗方法。广泛的生理方向应积极探索和考虑未来的管理性功能障碍。Burnett AL，Goldstein I，Andersson K-E，Argiolas A，Christ G，Park K，and Xin ZC.未来性医学生理治疗靶点。J Sex Med 2010;7：3269-3304.
Introduction.Sexual function in men and women incorporates physiologic processes and regulation of the central and peripheral nervous systems, the vascular system, and the endocrine system. There is need for state-of-the-art information as there is an evolving research understanding of the underlying molecular biological factors and mechanisms governing sexual physiologic functions.Aim.To develop an evidence-based, state-of-the-art consensus report on the current knowledge of the major cellular and molecular targets of biologic systems responsible for sexual physiologic function.Methods.State-of-the-art knowledge representing the opinions of seven experts from four countries was developed in a consensus process over a 2-year period.Main Outcome Measures.Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate.Results.Scientific investigation in this field is needed to increase knowledge and foster development of the future line of treatments for all forms of biological-based sexual dysfunction. This article addresses the current knowledge of the major cellular and molecular targets of biological systems responsible for sexual physiologic function. Future treatment targets include growth factor therapy, gene therapy, stem and cell-based therapies, and regenerative medicine.Conclusions.Scientific discovery is critically important for developing new and increasingly effective treatments in sexual medicine. Broad physiologic directions should be vigorously explored and considered for future management of sexual disorders. Burnett AL, Goldstein I, Andersson K-E, Argiolas A, Christ G, Park K, and Xin ZC. Future sexual medicine physiologic treatment targets. J Sex Med 2010;7:3269-3304.