Attention to painful stimulation enhances γ-band activity and synchronization in human sensorimotor cortex
Attention to painful stimulation enhances γ-band activity and synchronization in human sensorimotor cortex
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DOI：
10.1523/jneurosci.2283-07.2007
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发表时间：
2007-08-29
影响因子：
5.3
通讯作者：
Engel, Andreas K.
中科院分区：
文献类型：
--
作者：
Hauck, Michael;Lorenz, Juergen;Engel, Andreas K.
许多皮质区域参与处理与疼痛相关的信息。 SI和SII体感皮层主要处理感觉辨别属性，但在疼痛事件的识别和记忆中也发挥着重要作用。 SII 和后岛叶等区域似乎是第一个容纳注意力深刻影响行为反应和主观疼痛体验的过程的站点。我们使用脑磁图结合奇怪的范式，对 20 名健康受试者研究了定向注意力对疼痛引起的振荡和同步过程的影响。受试者的任务是计算施加在一根手指上的罕见的疼痛电刺激，同时忽略另一根手指上的频繁刺激。所有区块和受试者均观察到高检出率。随着刺激强度的增加和注意力的集中，δ带的早期诱发振荡增加，最明显的是在对侧感觉运动部位。此外，在疼痛刺激后观察到β活性的抑制和反弹。此外，高伽玛波段的诱发振荡活动随着直接注意力的增加而增加，与低刺激强度相比，高刺激强度的效果明显更强。针对这种高伽马响应进行的耦合分析揭示了注意力过程中同侧和对侧部位之间更强的功能相互作用。我们的结论是，疼痛引起的感觉运动区高频活动可能反映了处理的注意力增强，导致疼痛相关信号的显着性增强，从而使下游皮质中心更有效地处理这些信息。
A number of cortical regions are involved in processing pain-related information. The SI and SII somatosensory cortices process mainly sensory discriminative attributes but also play an important role in recognition and memory of painful events. Regions such as SII and the posterior insula appear to be the first stations that house processes by which attention profoundly shapes both behavioral responses and subjective pain experience. We investigated the influence of directed attention on pain-induced oscillations and synchronization processes using magnetoencephalogram in combination with an oddball paradigm in 20 healthy subjects. The subject's task was to count rare painful electrical stimuli applied to one finger, while ignoring frequent stimuli at a different finger. A high detection ratio was observed for all blocks and subjects. Early evoked oscillations in the delta-band increased with higher stimulus intensity and directed attention, most prominently at contralateral sensorimotor sites. Furthermore, suppression and rebound of beta activity were observed after painful stimulation. Moreover, induced oscillatory activity in the high gamma-band increased with directed attention, an effect being significantly stronger for high compared with low stimulus intensity. Coupling analysis performed for this high gamma response revealed stronger functional interactions between ipsilateral and contralateral sites during attention. We conclude that pain-induced high-frequency activity in sensorimotor areas may reflect an attentional augmentation of processing, leading to enhanced saliency of pain-related signals and thus to more efficient processing of this information by downstream cortical centers.