Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields.
Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields.
复制标题
铜绿假单胞菌突变体对铁对毒素 A 或弹性蛋白酶产量的影响的敏感性发生了改变。
DOI：
10.1128/jb.151.2.783-787.1982
复制
发表时间：
1982
影响因子：
3.2
通讯作者：
Iglewski,BH
中科院分区：
文献类型：
--
作者：
Sokol,PA;Cox,CD;Iglewski,BH
铁影响铜绿假单胞菌中毒素A、碱性蛋白酶、弹性蛋白酶、绿脓菌螯铁蛋白和绿脓菌荧光素的产量。分离出对铁对毒素（toxC）或弹性蛋白酶（elaC）产量的影响具有抗性的铜绿假单胞菌PAO 1的突变体。分离出两种类型的突变体：铁转运和铁调节突变体。toxC调节突变体在含铁的培养基中产生毒素A;然而，弹性蛋白酶和碱性蛋白酶的产量对铁的调节仍然敏感。elaC调节突变体的铁弹性蛋白酶产量的影响，但毒素A和碱性蛋白酶产量下降铁，类似的亲本菌株。这些数据表明，毒素A，弹性蛋白酶和碱性蛋白酶的产量可以独立调节铁。
Iron affects yields of toxin A, alkaline protease, elastase, pyochelin, and pyoverdin in Pseudomonas aeruginosa. Mutants of P. aeruginosa PAO1 resistant to the effect of iron on toxin (toxC) or elastase (elaC) yields were isolated. Two types of mutants were isolated: iron transport and iron regulatory mutants. The toxC regulatory mutants produced toxin A in medium containing iron; however, yields of elastase and alkaline protease remained sensitive to regulation by iron. The elaC regulatory mutants were resistant to the effect of iron on elastase yields, but toxin A and alkaline protease yields were decreased by iron, analogous to the parent strain. These data suggest that toxin A, elastase, and alkaline protease yields can be independently regulated by iron.