Antiphospholipid antibody syndrome in a six-year-old female patient.
Antiphospholipid antibody syndrome in a six-year-old female patient.
复制标题
一名六岁女性患者的抗磷脂抗体综合征。
DOI：
10.1016/s0002-9394(02)02078-0
复制
发表时间：
2003
影响因子：
4.2
通讯作者：
VanCott,Elizabeth
中科院分区：
文献类型：
--
作者：
Hartnett,MElizabeth;Laposata,Michael;VanCott,Elizabeth
目的报告首例原发性抗磷脂抗体 (APA) 综合征，发生在一名其他健康的 6 岁女性视网膜静脉血栓形成患者身上。设计观察病例报告。方法对左眼视力不佳且视网膜前出血的 6 岁女孩进行了感染性、自身免疫性和栓塞性疾病、糖尿病和高血压的检测。对 V 因子 Leiden 和凝血酶原 G20210A 突变、同型半胱氨酸、抗心磷脂抗体 (ACA)、狼疮抗凝物进行测试，并对蛋白 S、蛋白 C 和抗凝血酶 III 进行功能测定，以检测高凝状态。无需 IRB 批准。 结果 仅发现狼疮抗凝物阳性和 ACA IgG 中度升高。 18 个月后重复测试时，ACA IgG 适度升高。激光照射无灌注视网膜导致视网膜新生血管的部分消退。建议服用阿司匹林以降低未来血栓形成的风险。结论虽然不常见，但儿童视网膜血管血栓可在 APA 综合征中发生。应考虑检测 ACA 和狼疮抗凝剂。
PURPOSETo report the first instance of primary antiphospholipid antibody (APA) syndrome in an otherwise healthy 6-year-old female patient with retinal venous thromboses.DESIGNObservational case report.METHODSA 6-year-old girl with poor vision in the left eye and preretinal hemorrhage underwent testing for infectious, autoimmune and embolic disease, diabetes, and hypertension. Testing for factor V Leiden and prothrombin G20210A mutations, homocysteine, anticardiolipin antibodies (ACAs), lupus anticoagulant, and functional assays for protein S, protein C, and antithrombin III were performed to detect a hypercoagulable state. No IRB approval was necessary.RESULTSOnly a positive lupus anticoagulant and moderately elevated ACA IgG were found. The ACA IgG was moderately elevated on repeat testing 18 months later. Laser to nonperfused retina caused some regression of retinal neovascularization. Aspirin was recommended to reduce the risk of future thromboses.CONCLUSIONAlthough uncommon, retinovascular thrombosis in children can occur in APA syndrome. Testing for ACA and lupus anticoagulant should be considered.