Gamma-Delta T-Cell Lymphoma Following Allogeneic Stem Cell Transplant for Primary Myelofibrosis.
Gamma-Delta T-Cell Lymphoma Following Allogeneic Stem Cell Transplant for Primary Myelofibrosis.
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DOI：
10.7759/cureus.10301
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发表时间：
2020-09-07
期刊：
影响因子：
--
通讯作者：
Osswald M
中科院分区：
文献类型：
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作者：
Hoard R;Shahin G;Andreca FD;Osswald M
原发性骨髓纤维化(PMF)是一种影响骨髓的疾病。临床表现为细胞减少、肝细胞肿大并伴有髓外造血，常伴有躯体症状。细胞毒性伽马-德尔塔T细胞被认为是一种独特的肝脾淋巴细胞瘤。这是一个43岁男性的病例，最初诊断为PMF，他接受了同种异基因干细胞移植，并伴有原发移植失败。他随后接受了部分脾动脉栓塞术；然而，他很快患上了暴发性肝脾伽玛-三角洲T细胞淋巴瘤，导致他在死后被诊断为死亡。众所周知，PMF会转化为急性髓系白血病，但尚未确定与伽马-三角洲T细胞淋巴瘤有关。
Primary myelofibrosis (PMF) is a disease that affects the bone marrow. It presents with cytopenias, hepatospleomegaly accompanied with extramedullary hematopoiesis, and often with constitutional symptoms. Cytotoxic gamma-delta T-cells are considered a distinct hepatosplenic lymohoma. This is a case presentation of a 43-year-old male with an initial diagnosis of PMF who underwent allogeneic stem cell transplantation complicated by primary graft failure. He subsequently underwent a partial splenic embolization; however, he quickly developed a fulminant hepatosplenic gamma-delta T-cell lymphoma which led to his death that was diagnosed posthumously. PMF has been known to transform into an acute myeloid leukemia, but there has been no established link with gamma-delta T-cell lymphoma.