Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation
Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation
复制标题
DOI：
10.1177/0300060513477264
复制
发表时间：
2013-02
影响因子：
1.6
通讯作者：
Jia Yao;Xiao-wen Feng;Xiaobo Yu;Haiyang Xie;Li-Xian Zhu;Zhe Yang;B. Wei;Shu-sen Zheng;Lin Zhou
中科院分区：
文献类型：
--
作者：
Jia Yao;Xiao-wen Feng;Xiaobo Yu;Haiyang Xie;Li-Xian Zhu;Zhe Yang;B. Wei;Shu-sen Zheng;Lin Zhou
目的同种免疫反应引起的急性排斥反应是影响肝移植患者生存的主要危险因素。由于白细胞介素6（IL-6）可介导急性排斥反应，本研究旨在探讨IL-6基因单核苷酸多态性（SNPs）与肝移植受者急性排斥反应发生率的关系。方法对2005年1月至2010年12月接受肝移植的患者采用快照技术进行IL 6 - 572 C/G（rs 1800796）多态性分型。使用SNP统计网站：http://bioinfo.iconcologia.net/snpstats/start.htm分析基因型与急性排斥反应之间的关联。在335例肝移植后6个月内有或无急性排斥反应的患者中比较rs 1800796的等位基因和基因型分布。结果急性排斥反应发生率为11.94%。与纯合子CC或GG基因型相比，IL 6 - 572 C/G的杂合子CG基因型与较低的急性排斥反应率相关。结论IL 6 -572 CG基因型可能与中国汉族肝移植患者抗急性排斥反应有关。
Objective Acute rejection resulting from alloimmune responses is a major risk factor affecting patient survival following liver transplantation. Since interleukin (IL)-6 can mediate acute rejection, the association between IL-6 gene single nucleotide polymorphisms (SNPs) and incidence of acute rejection in liver transplant recipients was investigated. Methods Patients who received liver transplant between January 2005 and December 2010 were typed for IL6-572C/G (rs1800796) polymorphisms using the snapshot technique. Association between genotype and acute rejection was analysed using the SNP Statistics website: http://bioinfo.iconcologia.net/snpstats/start.htm. Allelic and genotypic distributions for rs1800796 were compared among 335 patients with or without acute rejection within the first 6 months following liver transplant. Results Incidence of acute rejection was 11.94%. A heterozygous CG genotype for IL6-572C/G was associated with a lower acute rejection rate compared with homozygous CC or GG genotypes. Conclusion IL6-572 CG genotype may be related to protection from acute rejection following liver transplant in Han Chinese patients.