Elevated cytokine levels in children with autism spectrum disorder
Elevated cytokine levels in children with autism spectrum disorder
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DOI：
10.1016/j.jneuroim.2005.11.007
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Wills-Karp, M
中科院分区：
文献类型：
--
作者：
Molloy, CA;Morrow, AL;Wills-Karp, M
本研究比较了20名自闭症谱系障碍儿童外周血单个核细胞中IL-2、IFN-γ、IL-4、IL-13、IL-5和IL-10的产生情况。所有Th 2细胞因子的水平显着更高的情况下，单独在培养基中孵育后，但IFN-γ/IL-13的比例是没有显着差异的情况下和对照组之间。IL-13/IL-10和IFN-γ/IL-10均显著高于对照组。结论：ASD儿童的适应性免疫应答的Th 2和Th 1臂的激活增加，Th 2占优势，并且调节细胞因子IL-10没有代偿性增加。(C)2005 Elsevier B. V.保留所有权利。
This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-gamma/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-gamma/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10. (C) 2005 Elsevier B.V. All rights reserved.