NOVEL SYNTHESIS OF CARBOCYCLIC OXETANOCIN ANALOGS (2-ALKOXY-C.OXT-A) AND THEIR TUBE FORMATION ACTIVITIES OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)
NOVEL SYNTHESIS OF CARBOCYCLIC OXETANOCIN ANALOGS (2-ALKOXY-C.OXT-A) AND THEIR TUBE FORMATION ACTIVITIES OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)
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DOI：
10.3987/com-12-12441
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发表时间：
2012-05
期刊：
影响因子：
0.6
通讯作者：
N. Sakakibara;I. Tsukamoto;T. Tsuruta
中科院分区：
文献类型：
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作者：
N. Sakakibara;I. Tsukamoto;T. Tsuruta
通过应用我们实验室开发的2-烷氧基腺苷衍生物（2）的从头合成，我们成功地有效合成了五种类型的2-烷氧基-C.OXT-A类似物（9，10a-d）。对于这些合成的化合物，使用人脐静脉内皮细胞评估了血管生成活性。四种产物（10a-d）增强了细胞的活性;特别是，浓度为100 μ M的2-甲氧基-C.OXT-A（10a）和2-异丙氧基-C.OXT-A（10 c）表现出与血管内皮细胞生长因子相同或更强的效力。
We succeeded in the effective synthesis of five types of 2-alkoxy-C.OXT-A analogs (9, 10a-d) by applying the de novo synthesis of 2-alkoxyadenosine derivatives (2), which was developed in our laboratory. For these synthesized compounds, the angiogenic activity was evaluated using human umbilical vein endothelial cells. Four products (10a-d) enhanced the activity of the cell; in particular, 2-methoxy-C.OXT-A (10a) and 2-isopropoxy-C.OXT-A (10c) at a concentration of 100 M exhibited the same or stronger potency than the vascular endothelial cell growth factor.