Association of Psoriasis Vulgaris with Sjögren's Syndrome
Association of Psoriasis Vulgaris with Sjögren's Syndrome
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寻常型银屑病与干燥综合征的关联
DOI：
10.1111/j.1346-8138.1998.tb02412.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
I. Katayama
中科院分区：
文献类型：
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作者：
Masahisa Watanabe;M. Shinohara;I. Katayama
致编辑：最近，银屑病与胶原性疾病如系统性红斑狼疮（SLE）、干燥综合征（SjS）和桥本甲状腺炎的相关性已有报道。我们描述了两例寻常型银屑病合并干燥综合征，并复习文献。病例报告：病例1：一位五十六岁男性，有十年的寻常型银屑病病史，于1997年8月出现面部弥漫性红斑。体格检查（包括光检查）未发现异常。实验室检查结果显示血细胞计数和血液化学正常。抗核抗体阳性，滴度为1：160（斑点）。抗SS-A和SS-B抗体阳性指数分别为33.0和31.7。抗ssDNA抗体和抗ds-DNA抗体均为阴性。在Shirmer或Rose-Bengal试验中未观察到异常反应。唇活检标本显示唾液腺导管周围局灶性单核细胞浸润和腺体纤维化（II级）。病例2：一位69岁的男性在诊断为寻常型银屑病的基础上接受了三年的治疗。1997年3月，随着银屑病病变的加重，他的躯干沿着出现环形红斑。环形红斑的组织病理学发现包括血管周围单核细胞的非特异性真皮浸润。抗核抗体阳性，滴度为1：40（斑点）。抗SS-A呈阳性，
To the Editor: Recently, an association of psoriasis with collagen diseases such as systemic lupus erythematosus (SLE) , Sjogren's syndrome (SjS), and Hashimoto's thyroiditis has been reported. We describe two cases of psoriasis vulgaris associated with Sjogren's syndrome and review the literature. Case Report: Case 1: A fifty-six year-old man with a ten-year history of psoriasis vulgaris developed diffuse erythema on the face in August of 1997. Physical examination including phototest revealed no abnormalities. The laboratory findings showed a normal blood cell count and blood chemistry. Antinuclear antibody was positive at a titer of 1:160 (speckled). Anti SS-Aand SS-B antibodies were also positive at an index of 33.0 (normal: 5-15 in our institute) and 31.7 (normal: 10-25) respectively. Anti-ssDNA antibody and anti-ds-DNA antibody were negative. No abnormal reaction was seen in Shirmer or Rose-Bengal tests. A lip biopsy specimen showed focal mononuclear cell infiltration around the salivary ducts and fibrosis of the gland (grade II). Case 2: A sixty-nine-year-old man had been treated for three years on the basis of a diagnosis of psoriasis vulgaris. In March of 1997, annular-shaped erythema developed on his trunk along with aggravation of the psoriatic lesion. The histopathological findings from the annular erythema included non-specific dermal infiltration of mononuclear cells around the blood vessels. Antinuclear antibody was positive at a titer of 1:40 (speckled). Anti SS-A was positive at an