How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells.
How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells.
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如何培育肺：应用发育生物学原理从人类多能干细胞生成肺谱系。
DOI：
10.1007/s40139-016-0102-x
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发表时间：
2016
影响因子：
--
通讯作者：
Spence,JasonR
中科院分区：
文献类型：
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作者：
Dye,BrianaR;Miller,AlyssaJ;Spence,JasonR
影响人类肺部发育和成人呼吸功能的疾病的数量和严重程度激发了人们对研究人类肺部的新体外模型的极大兴趣。这篇综述总结了通过指导人类多能干细胞的分化在培养皿中衍生肺谱系的最新突破。已经开发了多种培养平台，包括二维和三维（类器官）培养平台，以衍生肺部的特定细胞类型和结构。这些干细胞衍生的肺模型将进一步加深我们对人类肺发育、疾病和再生的理解。
The number and severity of diseases affecting human lung development and adult respiratory function has stimulated great interest in new in vitro models to study the human lung. This review summarizes the most recent breakthroughs deriving lung lineages in a dish by directing the differentiation of human pluripotent stem cells. A variety of culturing platforms have been developed, including two-dimensional and three-dimensional (organoid) culture platforms, to derive specific cell types and structures of the lung. These stem cell-derived lung models will further our understanding of human lung development, disease, and regeneration.