The extracellular matrix: at the center of it all.
The extracellular matrix: at the center of it all.
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DOI：
10.1016/j.yjmcc.2009.08.024
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发表时间：
2010-03
影响因子：
5
通讯作者：
Baudino TA
中科院分区：
文献类型：
--
作者：
Bowers SL;Banerjee I;Baudino TA
细胞外基质不仅是为细胞提供支持的支架，还参与细胞与细胞的相互作用、增殖和迁移。心脏的细胞和非细胞成分之间的复杂关系推动着心脏的正常发育、稳态和病理损伤后的恢复。心肌细胞、成纤维细胞和内皮细胞对特定的细胞外基质因子有不同的表达和反应，这些因子有助于细胞通讯和整体心脏功能。此外，ECM成分的周转和合成在心脏功能中起着重要作用。因此，更好地了解这些因素及其调控将有助于深入了解心脏发育和病理，并将为新的靶向药物治疗打开大门。这篇综述强调了特定的心脏细胞群和细胞外基质因子对心脏功能的发展和调节至关重要的重要性。
The extracellular matrix is not only a scaffold that provides support for cells, but it is also involved in cell–cell interactions, proliferation and migration. The intricate relationships among the cellular and acellular components of the heart drive proper heart development, homeostasis and recovery following pathological injury. Cardiac myocytes, fibroblasts and endothelial cells differentially express and respond to particular extracellular matrix factors that contribute to cell communication and overall cardiac function. In addition, turnover and synthesis of ECM components play an important role in cardiac function. Therefore, a better understanding of these factors and their regulation would lend insight into cardiac development and pathology, and would open doors to novel targeted pharmacologic therapies. This review highlights the importance of contributions of particular cardiac cell populations and extracellular matrix factors that are critical to the development and regulation of heart function.
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影响因子：
2.7
作者：
Beppu, Hideyuki;Malhotra, Rajeev;Beppu, Yuko;Lepore, John J.;Parmacek, Michael S.;Bloch, Kenneth D.
通讯作者：
Bloch, Kenneth D.
影响因子：
9.8
作者：
Astrof S;Hynes RO
通讯作者：
Hynes RO
影响因子：
4
作者：
Humphries JD;Byron A;Humphries MJ
通讯作者：
Humphries MJ
DOI：
10.1152/ajpheart.00514.2007
发表时间：
2007-09-01
影响因子：
4.8
作者：
Banerjee, Indroneal;Fuseler, John W.;Baudino, Troy A.
通讯作者：
Baudino, Troy A.
心脏成纤维细胞通过Beta1整合素信号传导调节心肌增殖。
影响因子：
11.8
作者：
Leda, Masaki;Tsuchihashi, Takatoshi;Ivey, Kathryn N.;Ross, Robert S.;Hong, Ting-Ting;Shaw, Robin M.;Srivastava, Deepak
通讯作者：
Srivastava, Deepak