FAMILIAL OCCURRENCE OF HEMATOLOGIC MALIGNANCIES AND OTHER DISEASES IN MULTIPLE-MYELOMA - A CASE-CONTROL STUDY
FAMILIAL OCCURRENCE OF HEMATOLOGIC MALIGNANCIES AND OTHER DISEASES IN MULTIPLE-MYELOMA - A CASE-CONTROL STUDY
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DOI：
10.1007/bf00051914
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发表时间：
1992-01-01
影响因子：
2.3
通讯作者：
HALLBERG, B
中科院分区：
文献类型：
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作者：
ERIKSSON, M;HALLBERG, B
在瑞典进行的一项基于人群的多发性骨髓瘤病例对照研究中，调查了亲属中不同疾病的发生率，特别是血液恶性肿瘤和不同类型的癌症。通过邮寄给所有活体受试者的调查问卷，即。通过对病例和对照组以及死亡受试者的近亲的调查，获得了亲属中恶性疾病和某些其他疾病的信息。一级亲属中报告的所有恶性疾病都尽可能通过教区当局和瑞典癌症登记处进行核实。总共分析了239例骨髓瘤患者和220例对照者的数据。一级亲属患恶性血液病的风险增加（相对风险[RR] = 2.36，90%置信区间[CI] = 0.90-6.15），尤其是多发性骨髓瘤（RR = 5.64，CI = 1.16-27.51）。如果近亲患有其他肿瘤疾病，则风险也会增加（RR = 1.21，CI = 0.86-1.71）。尤其是亲属中前列腺癌（RR = 3.11，CI = 1.25-7.71）或脑肿瘤（RR = 6.61，CI = 1.42-30.67）的发生增加了多发性骨髓瘤的风险。
In a population-based case-control study in Sweden on multiple myeloma, the occurrence of different diseases in relatives, particularly hematologic malignancies and different types of cancer, was investigated. Through a questionnaire mailed to all living subjects, ie. cases and controls, and to the next-of-kin for deceased subjects, information was obtained on malignant and certain other diseases among relatives. All malignant diseases reported among first-degree relatives were verified, if possible, through parochial authorities and the Swedish Cancer Register. In total, data from 239 cases with myeloma and 220 controls were analyzed. An increased risk was found for persons with first-degree relatives with hematologic malignancies (relative risk [RR] = 2.36, 90 percent confidence interval [CI] = 0.90-6.15), and also with multiple myeloma specifically (RR = 5.64, CI = 1.16-27.51). An increased risk also was seen if the close relatives had experienced another tumor disease (RR = 1.21, CI = 0.86-1.71). Particularly, occurrence of prostatic cancer (RR = 3.11, CI = 1.25-7.71) or brain tumor (RR = 6.61, CI = 1.42-30.67) in relatives increased the risk for multiple myeloma.