MITOTIC-ACTIVITY IN MONKEY AND RAT LEYDIG-CELLS
MITOTIC-ACTIVITY IN MONKEY AND RAT LEYDIG-CELLS
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DOI：
10.1051/rnd:19870808
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
KANN, ML
中科院分区：
文献类型：
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作者：
FOUQUET, JP;KANN, ML
用光学显微镜和电子显微镜检查了猴（Macaca fascicularis）从出生到成年和大鼠从青春期到成年的睾丸，以估计间质细胞的有丝分裂活性。在猴中，有丝分裂活性仅在新生儿中可测量：2.3.permill。睾丸间质细胞和0.4%。在成纤维细胞样细胞中。根据3 H-胸苷掺入的测量，新生动物（2%）和成年动物（1%）中的成熟Leydig细胞被标记。在青春期前（28日龄）和青春期（45日龄）大鼠，间质细胞的有丝分裂指数分别为2和0.2%，成纤维细胞样细胞和肌样细胞的有丝分裂指数分别为0.4和0.1%。在63日龄的青春期后大鼠中未检测到有丝分裂。综上所述，这些结果证明了成熟的Leydig细胞在正常发育过程中的自我更新能力。
The testes of the monkey, Macaca fascicularis, from birth to adulthood and of rats from puberty to adulthood were examined by both light and electron microscopy to estimate the mitotic activity of the Leydig cells. In monkeys, mitotic activity was measurable only in neonates: 2.3.permill. in Leydig cells and 0.4.permill. in fibroblast-like cells. From measurements of 3H-thymidine incorporation, mature Leydig cells were labeled in neonates (2%) and adult animals (1%). The labeling indices were significantly increased with increasing time after isotope exposure, and some pairs of labeled cells were found. In prepubertal (28 days of age) and pubertal (45 days of age), rats, mitotic indices were 2 and 0.2%, respectively, in the Leydig cells and 0.4 and 0.1% in fibroblast-like and myoid cells, respectively. Mitoses were not detected in postpubertal rats at 63 days of age. Taken together, these results demonstrate the self-renewal ability of mature Leydig cells during normal development.